Spots Global Cancer Trial Database for CPX-351 in Higher Risk Myelodysplastic Syndromes
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Trial Identification
Brief Title: CPX-351 in Higher Risk Myelodysplastic Syndromes
Official Title: CPX-351 in Higher Risk Myelodysplastic Syndromes: a Phase I/ II Study as First Line or After Hypomethylating-agents Failure
Study ID: NCT04273802
Conditions
Study Description
Brief Summary: Study of the efficacy of CPX-351 treatment in patients with higher risk myelodysplastic syndromes : as first line treatment or after hypomethylating agents failure
Detailed Description: A phase I/II study of the efficacy of CPX-351 treatment in patients with higher risk myelodysplastic syndromes : as first line treatment or after hypomethylating agents failure. CPX-351 is an advanced liposomal formulation of daunorubicin and cytarabine encapsulated at a 1:5 ratio. Patients will receive induction treatment with CPX-351. Patients in response (complete response (CR), complete response with incomplete hematologic improvement (CRi), partial response (PR)) after induction will receive monthly courses of consolidation therapy with CPX-351.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
CHU d'Amiens - Service d'hématologie clinique et thérapie cellulaire, Amiens, , France
CHU d'Angers - Service des maladies du sang, Angers, , France
Centre hospitalier Victor Dupouy - Service d'Hématologie, Argenteuil, , France
CHU de Besançon - Hôpital Jean Minjoz - Service d'hématologie clinique, Besançon, , France
CHU de Grenoble - Clinique universitaire d'hématologie, Grenoble, , France
CH Le Mans - Service d'onco-hématologie, Le Mans, , France
CHRU de Limoges - Hôpital Dupuytren - Service d'hématologie clinique et thérapie cellulaire, Limoges, , France
Institut Paoli Calmettes - Unité d'hématologie 3, Marseille, , France
CHU Hôtel Dieu - Service d'Hématologie Clinique, Nantes, , France
CHU-Hôpital Archet I - Service d'Hématologie Clinique, Nice, , France
Hôpital Saint Louis - Service Hématologie Séniors, Paris, , France
CHU de Bordeaux - Hôpital de Haut-Lévêque - Service des maladies du sang, Pessac, , France
CHU de Poitiers - Service d'onco-hématologie et thérapie cellulaire, Poitiers, , France
Hôpital Pontchaillou - Service d'hématologie clinique, Rennes, , France
Institut de Cancérologie Lucien Neuwirth - Hématologie Clinique - Thérapie Cellulaire, Saint Priest-en-Jarez, , France
IUCT-oncopole - Fédération Hématologie - Médecine Interne, Toulouse, , France
Contact Details
Name: Pierre PETERLIN, MD
Affiliation: Nantes University Hospital
Role: PRINCIPAL_INVESTIGATOR
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