Spots Global Cancer Trial Database for A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)
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Trial Identification
Brief Title: A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)
Official Title: A Phase 1b/2 Study of BMS-986158 Monotherapy and in Combination With Either Ruxolitinib or Fedratinib in Participants With DIPSS-Intermediate or High Risk Myelofibrosis
Study ID: NCT04817007
Conditions
Study Description
Brief Summary: The purpose of this study is to assess the safety, tolerability, and efficacy of BMS-986158 alone and in combination with either Ruxolitinib or Fedratinib in participants with Dynamic International Prognostic Scoring System (DIPSS)-intermediate or high risk blood cancer. Part 1 consists of BMS-986158 in combination with either Ruxolitinib or Fedratinib and Part 2 consists of BMS-986158 in combination with either Ruxolitinib or Fedratinib and BMS-986158 alone.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Local Institution - 0069, Newport Beach, California, United States
Local Institution - 0090, Lake Mary, Florida, United States
Local Institution - 0043, New Orleans, Louisiana, United States
Local Institution - 0038, Worcester, Massachusetts, United States
Local Institution - 0033, Ann Arbor, Michigan, United States
Local Institution - 0045, Hackensack, New Jersey, United States
Local Institution - 0076, Chapel Hill, North Carolina, United States
Local Institution - 0042, Pittsburgh, Pennsylvania, United States
Local Institution - 0036, Blacktown, New South Wales, Australia
Local Institution - 0032, Wollongong, New South Wales, Australia
Local Institution - 0007, East Melbourne, Victoria, Australia
Local Institution - 0006, Heidelberg, Victoria, Australia
Local Institution - 0041, Nedlands, Western Australia, Australia
Local Institution - 0015, West Perth, Western Australia, Australia
Local Institution - 0030, Brest, , France
Local Institution - 0008, Marseille, , France
Local Institution - 0027, Nice, , France
Local Institution - 0011, Paris, , France
Local Institution - 0010, Villejuif, , France
Local Institution - 0039, Essen, Nordrhein-Westfalen, Germany
Local Institution - 0035, Halle, Sachsen-Anhalt, Germany
Local Institution - 0040, Chemnitz, Sachsen, Germany
Local Institution - 0050, Lübeck, Schleswig-Holstein, Germany
Local Institution - 0068, Erding, , Germany
Local Institution - 0061, Chaidari, Attikí, Greece
Local Institution - 0047, Thessaloniki, Thessaloníki, Greece
Local Institution - 0073, Szeged, Csongrád, Hungary
Local Institution - 0072, Nyiregyhaza, Szabolcs-Szatmár-Bereg, Hungary
Local Institution - 0075, Budapest, , Hungary
Local Institution - 0074, Debrecen, , Hungary
Local Institution - 0086, Be'er Sheva, HaDarom, Israel
Local Institution - 0016, Jerusalem, , Israel
Local Institution - 0018, Petah-Tikva, , Israel
Local Institution - 0017, Ramat Gan, , Israel
Local Institution - 0019, Tel Aviv, , Israel
Local Institution - 0003, Bologna, , Italy
Local Institution - 0002, Brescia, , Italy
Local Institution - 0001, Firenze, , Italy
Local Institution - 0012, Verona, , Italy
Local Institution - 0049, Seongnam, Kyǒnggi-do, Korea, Republic of
Local Institution - 0048, Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0053, Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0077, Słupsk, Pomorskie, Poland
Local Institution - 0062, Gdańsk, , Poland
Local Institution - 0052, Bucuresti, Cluj, Romania
Local Institution - 0083, Bucuresti, , Romania
Local Institution - 0051, Cluj, , Romania
Local Institution - 0020, Badalona, Barcelona [Barcelona], Spain
Local Institution - 0054, Madrid, Madrid, Comunidad De, Spain
Local Institution - 0026, Madrid, , Spain
Local Institution - 0021, Salamanca, , Spain
Local Institution - 0029, Santander, , Spain
Local Institution - 0094, València, , Spain
Contact Details
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR
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