Spots Global Cancer Trial Database for A Clinical Research of LeY-Targeted CAR-T in Myeloid Malignancies
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Trial Identification
Brief Title: A Clinical Research of LeY-Targeted CAR-T in Myeloid Malignancies
Official Title: A Clinical Research of LeY-Targeted CAR-T in Myeloid Malignancies
Study ID: NCT02958384
Conditions
Interventions
Study Description
Brief Summary: The overall purpose of this study is to explore the therapeutic effect of LeY-targeted chimeric antigen receptor T(CAR-T) cells in the treatment of myeloid malignancies.
Detailed Description: Lewis -Y（LeY） is a difucosylated carbohydrate antigen and although its function is not known, it is expressed on a wide range of malignancies including myeloid malignancies. LeY-targeted CAR-T in myeloid malignancies had been explored and showed good efficiency in the treatment of myeloid malignancies. This trial is designed and conducted to test the safety and effectiveness of LeY-targeted CAR-T.
Keywords
Eligibility
Minimum Age: 14 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Southwest Hospital of Third Millitary Medical University, Chongqing, Chongqing, China
Contact Details
Name: Cheng Qian, MD, PhD
Affiliation: Biotherapy Center of Southwest Hospital
Role: PRINCIPAL_INVESTIGATOR
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