Spots Global Cancer Trial Database for Correlative Biomarker Study in Patients With Myeloproliferative Disorders
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Trial Identification
Brief Title: Correlative Biomarker Study in Patients With Myeloproliferative Disorders
Official Title: Correlative Biomarker Study for MPD-RC Treatment Studies in the Philadelphia Chromosome Negative MPD
Study ID: NCT00665067
Interventions
Study Description
Brief Summary: Researchers will use abnormal blood and/or bone marrow cells, or materials derived from these abnormal cells, like DNA, RNA, protein or plasma, in laboratory studies. Toenail clippings will provide normal material like DNA for comparison with the abnormal material derived from the blood and/or bone marrow. The results of these studies will be correlated with subjects' disease symptoms and response to their experimental treatment. The MPD-RC researchers are interested in studying molecules from the blood and bone marrow, the exact molecules changing over time with the investigators choosing only the most promising for investigation. The investigators are attempting to better understand the causes of MPD and to develop improved methods for the diagnosis and treatment of these diseases. These syndromes carry a high risk of developing leukemia. It is important to continue to learn more about these blood cancers and to learn more about the effectiveness and potential side effects of various treatments. It is believed that further basic knowledge about these cancer cells as well as the effects of treatment will lead to the improvement of current therapies and the development of entirely new treatments for these diseases. The MPD-RC is hoping to determine if a number of laboratory tests (biomarkers) will allow for the prediction of response in future patients to the treatment they would receive.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Mayo Clinic, Scottsdale, Arizona, United States
The Palo Alto Clinic, Palo Alto, California, United States
Georgetown University, Washington, District of Columbia, United States
Emory Hospital, Atlanta, Georgia, United States
University of Illinois at Chicago, Chicago, Illinois, United States
University of Maryland, Baltimore, Maryland, United States
Icahn School of Medicine at Mount Sinai, New York, New York, United States
Weill Cornell Medical College, New York, New York, United States
New York Blood Center, New York, New York, United States
Duke University Medical Center, Durham, North Carolina, United States
Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, United States
Ohio State University, Columbus, Ohio, United States
Geisinger Cancer Center, Hazleton, Pennsylvania, United States
University of Pennsylvania, Philadelphia, Pennsylvania, United States
University of Utah, Salt Lake City, Utah, United States
Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Ospedali Riuniti di Bergamo, Bergamo, , Italy
University of Florence, Florence, , Italy
Ospedale San Martino Genova, Genova, , Italy
San Matteo Hospital, Pavia, , Italy
Universita Cattolica del Sacro Cuore, Rome, , Italy
Guy's and St Thomas' NHS Foundation Trust, London, , United Kingdom
Contact Details
Name: Rona S Weinberg, PhD
Affiliation: Myeloproliferative Disorders-Research Consortium
Role: STUDY_CHAIR
Name: John Mascarenhas, MD
Affiliation: Icahn School of Medicine at Mount Sinai
Role: PRINCIPAL_INVESTIGATOR
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