Spots Global Cancer Trial Database for A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms
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Trial Identification
Brief Title: A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms
Official Title: A Phase 1, Open-Label, Multicenter Study of INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms
Study ID: NCT05936359
Conditions
Study Description
Brief Summary: This study is being conducted to evaluate the safety, tolerability, and dose-limiting toxicity (DLT) and determine the maximum tolerated dose (MTD) and/or recommended dose(s) for expansion (RDE) of INCA033989 administered as a monotherapy or in combination with ruxolitinib in participants with myeloproliferative neoplasms.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Royal Brisbane and Women'S Hospital, Herston, Queensland, Australia
Royal Adelaide Hospital, Adelaide, South Australia, Australia
Peter Maccallum Cancer Centre, Melbourne, Victoria, Australia
The Alfred Hospital, Melbourne, Victoria, Australia
Princess Margaret Cancer Center, Toronto, Ontario, Canada
Hopital Maisonneuve-Rosemont, Montreal, Qc, Montreal, Quebec, Canada
Odense University Hospital, Odense C, , Denmark
Sjaellands Universitetshospital, Roskilde, , Denmark
Vejle Hospital, Vejle, , Denmark
Institut Bergonie, Bordeaux, , France
Chu Nimes, Nimes, , France
Hospital Saint Louis, Paris, , France
Institut Gustave Roussy, Villejuif Cedex, , France
University Medical Center Rwth Aachen, Aachen, , Germany
Universitatsklinikum Halle (Saale), Halle, , Germany
Universitatsklinikum Ulm, ULM, , Germany
Azienda Ospedaliero-Universitaria Di Bologna Policlinico S. Orsola - Malpighi, Bologna, , Italy
Azienda Ospedaliero-Universitaria Careggi (Aouc), Firenze, , Italy
Fondazione Irccs Ca Granda Ospedale Maggiore, Milan, , Italy
National Cancer Center Hospital East, Chiba, , Japan
Kagoshima University Hospital, Kagoshima, , Japan
Osaka Metropolitan University Hospital, Osaka, , Japan
Nippon Medical School Hospital, Tokyo, , Japan
Mie University Hospital, TSU, , Japan
Hospital Universitario 12 de Octubre, Madrid, , Spain
Hospital Universitari I Politecnic La Fe, Valencia, , Spain
Guys and St Thomas Nhs Foundation Trust, London, , United Kingdom
The Christie Nhs Foundation Trust Uk, Manchester, , United Kingdom
University of Oxford, Oxford, , United Kingdom
Contact Details
Name: Incyte Medical Monitor
Affiliation: Incyte Corporation
Role: STUDY_DIRECTOR
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