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Spots Global Cancer Trial Database for Novel MRE Technique to Assess a Risk Factor for Liver Cancer

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Trial Identification

Brief Title: Novel MRE Technique to Assess a Risk Factor for Liver Cancer

Official Title: Novel MRE Technique to Assess Tissue Viscoelasticity as a Risk Factor for Liver Cancer

Study ID: NCT05165446

Interventions

Study Description

Brief Summary: The aim of this proposal is to investigate a novel imaging method to identify patients with non-alcoholic steatohepatitis (NASH) who are at risk for hepatocellular carcinoma (HCC).

Detailed Description: NASH is the most common cause of chronic liver disease, and it is estimated that 40-50% of patients with obesity and T2DM have NASH. NASH can lead to HCC with the risk increasing 2-3 fold in patient with poor glycemic control. Unless caught early, HCC has a poor prognosis with no effective therapies. A unique feature of HCC in NASH is that it often arises at a pre-cirrhotic stage, and the prognosis is often dismal. There are no current surveillance strategies for these pre-cirrhotic patients. Based on our animal models and pilot patient studies, we developed a novel paradigm that linked liver matrix changes to a more aggressive HCC phenotype. Our goal is to develop an imaging-based surveillance tool that will identify early matrix changes that may predispose to HCC.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Stanford Hospital, Stanford, California, United States

Contact Details

Name: Natalie Torok, MD

Affiliation: Stanford University

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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