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Brief Title: Novel MRE Technique to Assess a Risk Factor for Liver Cancer
Official Title: Novel MRE Technique to Assess Tissue Viscoelasticity as a Risk Factor for Liver Cancer
Study ID: NCT05165446
Brief Summary: The aim of this proposal is to investigate a novel imaging method to identify patients with non-alcoholic steatohepatitis (NASH) who are at risk for hepatocellular carcinoma (HCC).
Detailed Description: NASH is the most common cause of chronic liver disease, and it is estimated that 40-50% of patients with obesity and T2DM have NASH. NASH can lead to HCC with the risk increasing 2-3 fold in patient with poor glycemic control. Unless caught early, HCC has a poor prognosis with no effective therapies. A unique feature of HCC in NASH is that it often arises at a pre-cirrhotic stage, and the prognosis is often dismal. There are no current surveillance strategies for these pre-cirrhotic patients. Based on our animal models and pilot patient studies, we developed a novel paradigm that linked liver matrix changes to a more aggressive HCC phenotype. Our goal is to develop an imaging-based surveillance tool that will identify early matrix changes that may predispose to HCC.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Stanford Hospital, Stanford, California, United States
Name: Natalie Torok, MD
Affiliation: Stanford University
Role: PRINCIPAL_INVESTIGATOR