Spots Global Cancer Trial Database for Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients

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Trial Identification

Brief Title: Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients

Official Title: Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients Pre and Post Concurrent Chemo-radiation Therapy

Study ID: NCT02854410

Conditions

Nasopharyngeal Carcinoma

Interventions

Sodium nitrate

sodium chloride

Study Description

Brief Summary: The purpose of this study is to evaluate whether dietary nitrate supplementation could improve the salivary flow for nasopharyngeal carcinoma patients receiving concurrent chemo-radiation therapy.

Detailed Description: Thirty patients diagnosed as nasopharyngeal carcinoma will be recruited. Nitrate supplement(Sodium nitrate: 0.5 mmol/kgbodyweight,bid) or placebo(sodium chloride: 0.5 mmol/kgbodyweight,bid) will be provided to the patients from 7 days before radiotherapy to one month after the finish of radiotherapy . The salivary flow and plasma nitrate levels will be determined before the course of nitrate supplementation and radiotherapy,before the course of radiotherapy,post the course of radiotherapy immediately and one month after the finish of radiotherapy.