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Spots Global Cancer Trial Database for Bacterial Decolonization to Prevent Radiation-induced Oral Mucositis

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Trial Identification

Brief Title: Bacterial Decolonization to Prevent Radiation-induced Oral Mucositis

Official Title: Bacterial Decolonization to Prevent Radiation-induced Oral Mucositis: A Randomized Controlled Trial and Quality of Life Assessment

Study ID: NCT05893810

Interventions

Mupirocin Ointment

Study Description

Brief Summary: The purpose of this study is to determine whether bacterial decolonization of the nares prior to treatment with radiotherapy (RT) for patients with nasopharyngeal carcinoma, can prevent high-grade radiation-induced oral mucositis (RIOM) and improve quality of life. This study is being conducted because a randomized clinical trials form Yana Kost et al. have found bacterial decolonization in the nose prior to initiation of RT was effective for prevention of acute radiation dermatitis. Patients in the treatment arm will receive pretreatment with mupirocin ointment to the nares while patients in the control arm will receive standard of care treatment. Bacterial cultures will be taken from the nares and mouth, and participants will also complete a quality of life questionnaire before and after RT.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Jiangxi Cancer Hospital, Nanchang, Jiangxi, China

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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