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Spots Global Cancer Trial Database for Sintilimab (PD-1 Antibody) and Chemoradiotherapy in Locoregionally-advanced Nasopharyngeal Carcinoma

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Trial Identification

Brief Title: Sintilimab (PD-1 Antibody) and Chemoradiotherapy in Locoregionally-advanced Nasopharyngeal Carcinoma

Official Title: Sintilimab (PD-1 Antibody) and Chemoradiotherapy in Locoregionally-advanced Nasopharyngeal Carcinoma: a Randomized, Multicenter, Phase 3 Trial

Study ID: NCT03700476

Study Description

Brief Summary: The CONTINUUM trial plans to enroll patients with stage III-IVA (AJCC 8th, except T3N0-1 or T4N0) locoregionally-advanced nasopharyngeal carcinoma (LANPC). Patients will be randomized in a 1:1 ratio to receive 3 cycles of induction chemotherapy with gemcitabine and cisplatin and concurrent cisplatin-radiation or the same regimen plus Sintilimab. All patients will receive intensity-modulated radiotherapy (IMRT). Sintilimab will begin on day 1 of induction chemotherapy and continue every 3 weeks for 12 cycles.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

First People's Hospital of Foshan, Foshan, Guangdong, China

Panyu central hospital, Guangzhou, Guangdong, China

SUN YAT-SEN UNIVERSITY cANCER CENTER, Guangzhou, Guangdong, China

Cancer Hospital of Guangxi Medical University, Nanning, Guangxi, China

Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China

Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China

Xiangya Hospital Central South University, Changsha, Hunan, China

Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi, China

West China Hospital, Sichuan University, Chengdu, Sichuan, China

Contact Details

Name: Jun Ma, MD

Affiliation: Sun Yat-sen University

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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