Spots Global Cancer Trial Database for Induction Immunochemotherapy in Stage III-IVa Head and Neck Cancer
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Trial Identification
Brief Title: Induction Immunochemotherapy in Stage III-IVa Head and Neck Cancer
Official Title: Induction Immunochemotherapy in Stage III-IVa Cancer of Oropharynx, Hypopharynx and Larynx
Study ID: NCT05551767
Conditions
Interventions
Study Description
Brief Summary: patients with locally advanced cancer of oropharynx, hypopharynx or larynx and CPS\>1 will recieve 3 cycles of induction immunochemotherapy with platinum, 5-FU and pembrolizumab followed by (chemo)radiation.
Detailed Description: patients with locally advanced cancer of oropharynx, hypopharynx or larynx and CPS\>1 will recieve 3 cycles of induction immunochemotherapy with platinum (cisplatin 75 mg\\m2, 5-FU 1000 mg/m2/day 96-hour infusion and pembrolizumab 200 mg) followed by (chemo)radiation. Effect of induction therapy will be assesed by PET/CT and by endoscopic evaluation with biopsy of suspected residual tumor. Managemant of any residual tumor will be performed according with local rules and standards.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Moscow Clinical Scientific Center named after Loginov, Moscow, , Russian Federation
City clinical oncology hospital 1, Moscow, , Russian Federation
Moscow City Oncology Hospital No 62, Moscow, , Russian Federation
Contact Details
Name: Vsevolod N Galkin, Professor
Affiliation: City Clinical Oncology Hospital No 1
Role: PRINCIPAL_INVESTIGATOR
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