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Spots Global Cancer Trial Database for Side Population in Pancreatic Ductal Adenocarcinoma (PDAC)

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Trial Identification

Brief Title: Side Population in Pancreatic Ductal Adenocarcinoma (PDAC)

Official Title: Prognostic and Therapeutic Relevance of the 'Side Population' in Pancreatic Cancer

Study ID: NCT00936104

Interventions

Study Description

Brief Summary: In the current project we aim to study the oncological process of pancreatic cancer, from a perspective of the CSC-theory and in particular through the 'side population' (SP)-approach. The SP seems to be enriched for CSC and doesn't a priori exclude any CSC-subpopulation. After isolation from pancreatic cancer resection specimens, SP cells will be characterized by gene-expression profiling based on microarray analysis. We'll identify markers and pathways (with emphasis for stem cell and cancer -related ones) that are differentially expressed in SP versus the rest of tumour cells (the 'main population' or MP). In order to assess the prognostic relevance of the SP, we'll study these genes using the high-throughput Nanostring technology in about 200 snap-frozen PDAC resection specimens of patients from our prospective database. Finally, two monoclonal antibodies (mAB) will be tested as novel therapeutic agents in vivo (mouse model), wherein the choice of mAB will be based on prognostically relevant molecular targets and pathways obtained from the Nanostring results.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University Hospital Leuven, Leuven, Vlaams-Brabant, Belgium

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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