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Brief Title: Paclitaxel With / Without GW572016 (Lapatinib) As First Line Therapy For Women With Advanced Or Metastatic Breast Cancer
Official Title: A Randomized, Multicenter, Double-Blind, Placebo-Controlled, 2-Arm, Phase III Study of Oral GW572016 in Combination With Paclitaxel in Subjects Previously Untreated or Advanced or Metastatic Breast Cancer
Study ID: NCT00075270
Brief Summary: The purpose of this study is to determine the efficacy and safety of an oral dual tyrosine kinase inhibitor (GW572016) in combination with paclitaxel compared to paclitaxel alone in first line advanced or metastatic breast cancer.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
GSK Investigational Site, Tucson, Arizona, United States
GSK Investigational Site, Hot Springs, Arkansas, United States
GSK Investigational Site, Jonesboro, Arkansas, United States
GSK Investigational Site, Fountain Valley, California, United States
GSK Investigational Site, La Jolla, California, United States
GSK Investigational Site, Rancho Mirage, California, United States
GSK Investigational Site, Vallejo, California, United States
GSK Investigational Site, Denver, Colorado, United States
GSK Investigational Site, Boca Raton, Florida, United States
GSK Investigational Site, Orlando, Florida, United States
GSK Investigational Site, Port St. Lucie, Florida, United States
GSK Investigational Site, West Palm Beach, Florida, United States
GSK Investigational Site, Atlanta, Georgia, United States
GSK Investigational Site, Marietta, Georgia, United States
GSK Investigational Site, Savannah, Georgia, United States
GSK Investigational Site, Savannah, Georgia, United States
GSK Investigational Site, Indianapolis, Indiana, United States
GSK Investigational Site, Kansas City, Kansas, United States
GSK Investigational Site, Metairie, Louisiana, United States
GSK Investigational Site, Baltimore, Maryland, United States
GSK Investigational Site, Glen Burnie, Maryland, United States
GSK Investigational Site, Springfield, Massachusetts, United States
GSK Investigational Site, Duluth, Minnesota, United States
GSK Investigational Site, Robbinsdale, Minnesota, United States
GSK Investigational Site, St. Louis, Missouri, United States
GSK Investigational Site, Voorhees, New Jersey, United States
GSK Investigational Site, Santa Fe, New Mexico, United States
GSK Investigational Site, Nyack, New York, United States
GSK Investigational Site, Syracuse, New York, United States
GSK Investigational Site, Charlotte, North Carolina, United States
GSK Investigational Site, Greenville, North Carolina, United States
GSK Investigational Site, Fargo, North Dakota, United States
GSK Investigational Site, Canton, Ohio, United States
GSK Investigational Site, Portland, Oregon, United States
GSK Investigational Site, Columbia, South Carolina, United States
GSK Investigational Site, Knoxville, Tennessee, United States
GSK Investigational Site, Knoxville, Tennessee, United States
GSK Investigational Site, Amarillo, Texas, United States
GSK Investigational Site, Fort Worth, Texas, United States
GSK Investigational Site, Houston, Texas, United States
GSK Investigational Site, San Antonio, Texas, United States
GSK Investigational Site, Burlington, Vermont, United States
GSK Investigational Site, Norfolk, Virginia, United States
GSK Investigational Site, Tacoma, Washington, United States
GSK Investigational Site, Milwaukee, Wisconsin, United States
GSK Investigational Site, Capital Federal, Buenos Aires, Argentina
GSK Investigational Site, Capital Federal, Buenos Aires, Argentina
GSK Investigational Site, Buenos Aires, , Argentina
GSK Investigational Site, Fitzroy, Victoria, Australia
GSK Investigational Site, Malvern, Victoria, Australia
GSK Investigational Site, Wodonga, Victoria, Australia
GSK Investigational Site, Nedlands, Western Australia, Australia
GSK Investigational Site, Vienna, , Austria
GSK Investigational Site, Brugge, , Belgium
GSK Investigational Site, Brussels, , Belgium
GSK Investigational Site, Brussel, , Belgium
GSK Investigational Site, Kortrijk, , Belgium
GSK Investigational Site, Leuven, , Belgium
GSK Investigational Site, Roeselare, , Belgium
GSK Investigational Site, Salvador, Bahía, Brazil
GSK Investigational Site, Rio de Janeiro, , Brazil
GSK Investigational Site, Saint John's, Newfoundland and Labrador, Canada
GSK Investigational Site, Sudbury, Ontario, Canada
GSK Investigational Site, Thunder Bay, Ontario, Canada
GSK Investigational Site, Montreal, Quebec, Canada
GSK Investigational Site, Montreal, Quebec, Canada
GSK Investigational Site, Sherbrooke, Quebec, Canada
GSK Investigational Site, Santiago, Región Metro De Santiago, Chile
GSK Investigational Site, Santiago, Región Metro De Santiago, Chile
GSK Investigational Site, Santiago, Región Metro De Santiago, Chile
GSK Investigational Site, Brno, , Czech Republic
GSK Investigational Site, Hradec Kralove, , Czech Republic
GSK Investigational Site, Olomouc, , Czech Republic
GSK Investigational Site, Aalen, Baden-Wuerttemberg, Germany
GSK Investigational Site, Stuttgart, Baden-Wuerttemberg, Germany
GSK Investigational Site, Ulm, Baden-Wuerttemberg, Germany
GSK Investigational Site, Augsburg, Bayern, Germany
GSK Investigational Site, Bayreuth, Bayern, Germany
GSK Investigational Site, Coburg, Bayern, Germany
GSK Investigational Site, Muenchen, Bayern, Germany
GSK Investigational Site, Muenchen, Bayern, Germany
GSK Investigational Site, Fuerstenwalde, Brandenburg, Germany
GSK Investigational Site, Stade, Niedersachsen, Germany
GSK Investigational Site, Herne, Nordrhein-Westfalen, Germany
GSK Investigational Site, Ibbenbueren, Nordrhein-Westfalen, Germany
GSK Investigational Site, Muenster, Nordrhein-Westfalen, Germany
GSK Investigational Site, Halle, Sachsen-Anhalt, Germany
GSK Investigational Site, Kiel, Schleswig-Holstein, Germany
GSK Investigational Site, Jena, Thueringen, Germany
GSK Investigational Site, Berlin, , Germany
GSK Investigational Site, Berlin, , Germany
GSK Investigational Site, Berlin, , Germany
GSK Investigational Site, Berlin, , Germany
GSK Investigational Site, Hamburg, , Germany
GSK Investigational Site, Hamburg, , Germany
GSK Investigational Site, Hamburg, , Germany
GSK Investigational Site, Budapest, , Hungary
GSK Investigational Site, Nyíregyháza, , Hungary
GSK Investigational Site, Szombathely, , Hungary
GSK Investigational Site, Zalaegerszeg-Pózva, , Hungary
GSK Investigational Site, Benevento, Campania, Italy
GSK Investigational Site, Napoli, Campania, Italy
GSK Investigational Site, Forlì, Emilia-Romagna, Italy
GSK Investigational Site, Parma, Emilia-Romagna, Italy
GSK Investigational Site, Ravenna, Emilia-Romagna, Italy
GSK Investigational Site, Rimini, Emilia-Romagna, Italy
GSK Investigational Site, Roma, Lazio, Italy
GSK Investigational Site, Roma, Lazio, Italy
GSK Investigational Site, Pietra Ligure (SV), Liguria, Italy
GSK Investigational Site, Bergamo, Lombardia, Italy
GSK Investigational Site, Pavia, Lombardia, Italy
GSK Investigational Site, Candiolo (TO), Piemonte, Italy
GSK Investigational Site, Torino, Piemonte, Italy
GSK Investigational Site, Sassari, Sardegna, Italy
GSK Investigational Site, Prato (PO), Toscana, Italy
GSK Investigational Site, Perugia, Umbria, Italy
GSK Investigational Site, Gyeonggi-do, , Korea, Republic of
GSK Investigational Site, Seoul, , Korea, Republic of
GSK Investigational Site, Daugavpils, , Latvia
GSK Investigational Site, Liepaja, , Latvia
GSK Investigational Site, Riga, , Latvia
GSK Investigational Site, Riga, , Latvia
GSK Investigational Site, Acapulco, Guerrero, Mexico
GSK Investigational Site, Guadalajara, Jalisco, Mexico
GSK Investigational Site, Colima, , Mexico
GSK Investigational Site, Durango, , Mexico
GSK Investigational Site, Amersfoort, , Netherlands
GSK Investigational Site, Leiden, , Netherlands
GSK Investigational Site, Nieuwegein, , Netherlands
GSK Investigational Site, Utrecht, , Netherlands
GSK Investigational Site, Utrecht, , Netherlands
GSK Investigational Site, Auckland, , New Zealand
GSK Investigational Site, Christchurch, , New Zealand
GSK Investigational Site, Lahore, , Pakistan
GSK Investigational Site, Lahore, , Pakistan
GSK Investigational Site, Callao, , Peru
GSK Investigational Site, Lima, , Peru
GSK Investigational Site, Krakow, , Poland
GSK Investigational Site, Olsztyn, , Poland
GSK Investigational Site, Olsztyn, , Poland
GSK Investigational Site, Poznan, , Poland
GSK Investigational Site, Warszawa, , Poland
GSK Investigational Site, Wroclaw, , Poland
GSK Investigational Site, Moscow Region, , Russian Federation
GSK Investigational Site, Moscow, , Russian Federation
GSK Investigational Site, Moscow, , Russian Federation
GSK Investigational Site, Moscow, , Russian Federation
GSK Investigational Site, Moscow, , Russian Federation
GSK Investigational Site, Moscow, , Russian Federation
GSK Investigational Site, St. Petersburg, , Russian Federation
GSK Investigational Site, St. Petersburg, , Russian Federation
GSK Investigational Site, Banska Bystrica, , Slovakia
GSK Investigational Site, Bratislava, , Slovakia
GSK Investigational Site, Kosice, , Slovakia
GSK Investigational Site, Poprad, , Slovakia
GSK Investigational Site, Parktown, Gauteng, South Africa
GSK Investigational Site, Capital Park, , South Africa
GSK Investigational Site, Overport, , South Africa
GSK Investigational Site, Parow, , South Africa
GSK Investigational Site, Port Elizabeth, , South Africa
GSK Investigational Site, Alcorcón/Madrid, , Spain
GSK Investigational Site, Baracaldo/Vizcaya, , Spain
GSK Investigational Site, Caceres, , Spain
GSK Investigational Site, Cuidad Real, , Spain
GSK Investigational Site, Jaen, , Spain
GSK Investigational Site, La Laguna (Santa Cruz de Tenerife), , Spain
GSK Investigational Site, Las Palmas De Gran Canaria, , Spain
GSK Investigational Site, Madrid, , Spain
GSK Investigational Site, Móstoles/Madrid, , Spain
GSK Investigational Site, Palma de Mallorca, , Spain
GSK Investigational Site, Pontevedra, , Spain
GSK Investigational Site, San Sebastián, , Spain
GSK Investigational Site, Santa Cruz de Tenerife, , Spain
GSK Investigational Site, Zaragoza, , Spain
GSK Investigational Site, Zaragoza, , Spain
GSK Investigational Site, Istanbul, , Turkey
GSK Investigational Site, Istanbul, , Turkey
Name: GSK Clinical Trials
Affiliation: GlaxoSmithKline
Role: STUDY_DIRECTOR