Spots Global Cancer Trial Database for A Pharmacokinetic Study of Valacyclovir in Pediatric Oncology Patients

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Trial Identification

Brief Title: A Pharmacokinetic Study of Valacyclovir in Pediatric Oncology Patients

Official Title: A Pharmacokinetic Study of Valacyclovir in Pediatric Oncology Patients

Study ID: NCT00042328

Conditions

Neoplasms

Interventions

Valacyclovir

Study Description

Brief Summary: The purpose of this research is to study the pharmacology (how the body handles this drug) of valacyclovir in children receiving treatment for cancer. This study will last approximately 7 days.

Detailed Description: In this study, patients will receive a single dose of oral valacyclovir. Blood samples will be drawn to evaluate the pharmacology (how the body handles the drug). Blood samples (less than one teaspoon each) will be obtained before receiving the drug and at 0.5, 1, 1.5, 2, 5, 6, and 8 hours after receiving the drug. The total amount of blood drawn from patients for all blood work including routine blood tests as well as pharmacokinetics will not be greater than 5% of the total blood volume. We will also have all urine output collected for 8 hours starting at the time patients receive the dose of valacyclovir. A 5cc sample of urine will be collected and analyzed to determine how the body handles the drug at hours 2, 4, 6, and 8.