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Brief Title: The Effect of Resistance Training and Aerobic Training on Body Composition During Chemotherapy
Official Title: The Effect of Resistance Training and Aerobic Training on Body Composition During Chemotherapy
Study ID: NCT02192216
Brief Summary: Chemotherapy can induce muscle loss in colorectal, breast and advanced renal cell carcinoma patients. The Danish nation-wide training and rehabilitation offer 'Body \& Cancer' offers intensive resistance and endurance training to all Danish cancer patients receiving chemotherapy with the aim of reducing treatment-related fatigue and physical impairments, but the potential of the training to preserve or improve muscle mass is uninvestigated. Furthermore, the underlying biological mechanisms of treatment and/or exercise induced changes in muscle mass in cancer patients remains uninvestigated. Thus, the primary purpose of the present study is to investigate changes in body composition during chemotherapy and after resistance and aerobic training combined with protein supplementation during ongoing chemotherapy in cancer patients. Secondly, we aim to investigate the underlying biological mechanisms of muscle mass regulation in biopsies obtained before and after a control period as well as after 10 weeks of exercise, both during chemotherapy. We hypothesize that 10 weeks exercise will improve muscle mass and body composition in cancer patients during chemotherapy as compared to a control period during chemotherapy alone.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Dept of Oncology, Aarhus University Hospital, Aarhus C, , Denmark
Name: Simon Loenbro, M.Sc., PhD
Affiliation: Dept. of Public Health, Sect. for Sports Science, Aarhus University
Role: PRINCIPAL_INVESTIGATOR