Spots Global Cancer Trial Database for Studying Gene Expression in Samples From Younger Patients With Neuroblastoma
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Trial Identification
Brief Title: Studying Gene Expression in Samples From Younger Patients With Neuroblastoma
Official Title: The Role of Stroma-Derived Soluble TßRIII in Neuroblastoma
Study ID: NCT01553448
Study Description
Brief Summary: RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer. PURPOSE: This research trial studies gene expression in samples from younger patients with neuroblastoma.
Detailed Description: OBJECTIVES: * Determine whether TβRIII expression and TGF-β signaling decrease in advanced-stage neuroblastoma (NBL) and whether these changes are confined to the Schwannian stroma. * Determine whether sTβRIII levels and TGF-β signaling correlate with NBL stage, tumor stroma content, surface TβRIII expression, and TGF-β signaling. OUTLINE: Archived paraffin-embedded tissue and plasma samples are analyzed for TβRIII expression, TGF-β signaling, and SMAD3 expression and phosphorylation by immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), and other assays. Surface expression of TβRIII in the neuroblastic and stromal tumor components are correlated with matched circulating levels of soluble TβRIII. Results are then correlated with each patient's outcome data, including stage.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Contact Details
Name: Gerard C. Blobe, MD, PhD
Affiliation: Duke University
Role: PRINCIPAL_INVESTIGATOR
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