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Spots Global Cancer Trial Database for Biomarkers in Samples From Young Patients With Neuroblastoma

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Biomarkers in Samples From Young Patients With Neuroblastoma

Official Title: ROR1 as a Novel Target for Neuroblastoma

Study ID: NCT01358604

Conditions

Neuroblastoma

Study Description

Brief Summary: RATIONALE: Studying samples of tissue and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study studies biomarkers in samples from young patients with neuroblastoma.

Detailed Description: OBJECTIVES: Primary * To analyze the expression of ROR1 on the surface of primary neuroblastoma cells. * To investigate the therapeutic potential of anti-ROR1 monoclonal antibodies (mAbs), bispecific antibodies, and immunotoxins in in vitro and in vivo models of neuroblastoma. OUTLINE: Archived bone marrow and tumor tissue samples are analyzed for ROR1 expression by flow cytometry, western blotting, qPCR, and IHC.

Eligibility

Minimum Age:

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Contact Details

Name: David Hema, MD, MPH

Affiliation: NCI - Experimental Transplantation and Immunology Branch

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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