Spots Global Cancer Trial Database for Studying Biomarkers in Samples From Patients With High-Risk Neuroblastoma

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Trial Identification

Brief Title: Studying Biomarkers in Samples From Patients With High-Risk Neuroblastoma

Official Title: Alternative Lengthening of Telomeres (ALT) in Neuroblastoma

Study ID: NCT01510600

Conditions

Neuroblastoma

Interventions

DNA analysis

polymerase chain reaction

laboratory biomarker analysis

medical chart review

Study Description

Brief Summary: RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies biomarkers in samples from patients with high-risk neuroblastoma.

Detailed Description: OBJECTIVES: * To establish telomere length measurement by quantitative polymerase chain reaction (qPCR) as an alternative lengthening of telomeres (ALT) detection method in neuroblastoma (NB). * To determine the frequency of ALT in high-risk NB and the characteristics of ALT+ NB. * To establish C-circle (extra-chromosomal telomeric DNA circles) level as a marker of ALT activity in NB. * To evaluate the prognostic significance of ALT in NB. * To evaluate the utility of the C-circle assay for the detection of circulating tumor DNA in NB patients with an ALT+ tumor. OUTLINE: Archived tumor tissue and serum samples are analyzed for telomere length measurement, frequency, and C-circle levels by PCR. Results are then compared with patients' age at diagnosis and outcomes including survival data (event-free and overall survival).