Spots Global Cancer Trial Database for PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
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Trial Identification
Brief Title: PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
Official Title: PEACH TRIAL- Precision mEdicine and Adoptive Cellular tHerapy for the Treatment of Recurrent Neuroblastoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG)
Study ID: NCT04837547
Study Description
Brief Summary: A Phase I open-label, multicenter study, to evaluate the safety, feasibility, and maximum tolerated dose (MTD) of treating children with newly diagnosed DIPG or recurrent neuroblastoma with molecular targeted therapy in combination with adoptive cell therapy (Total tumor mRNA-pulsed autologous Dendritic Cells (DCs) (TTRNA-DCs), Tumor-specific ex vivo expanded autologous lymphocyte transfer (TTRNA-xALT) and Autologous G-CSF mobilized Hematopoietic Stem Cells (HSCs)).
Detailed Description:
Keywords
Eligibility
Minimum Age: 1 Year
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Florida, Gainesville, Florida, United States
Levine Children's Hospital, Charlotte, North Carolina, United States
Penn State Milton S. Hershey Medical Center and Children's Hospital, Hershey, Pennsylvania, United States
Contact Details
Name: Giselle Sholler, MD
Affiliation: Beat Childhood Cancer at Atrium Health
Role: STUDY_CHAIR
Name: Duane Mitchell, M.D., Ph.D.
Affiliation: University of Florida
Role: STUDY_CHAIR
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