Spots Global Cancer Trial Database for Biomarkers in Samples From Young Patients With Neuroblastoma
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Trial Identification
Brief Title: Biomarkers in Samples From Young Patients With Neuroblastoma
Official Title: ROR1 as a Novel Target for Neuroblastoma
Study ID: NCT01358604
Conditions
Study Description
Brief Summary: RATIONALE: Studying samples of tissue and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study studies biomarkers in samples from young patients with neuroblastoma.
Detailed Description: OBJECTIVES: Primary * To analyze the expression of ROR1 on the surface of primary neuroblastoma cells. * To investigate the therapeutic potential of anti-ROR1 monoclonal antibodies (mAbs), bispecific antibodies, and immunotoxins in in vitro and in vivo models of neuroblastoma. OUTLINE: Archived bone marrow and tumor tissue samples are analyzed for ROR1 expression by flow cytometry, western blotting, qPCR, and IHC.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Contact Details
Name: David Hema, MD, MPH
Affiliation: NCI - Experimental Transplantation and Immunology Branch
Role: PRINCIPAL_INVESTIGATOR
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