Spots Global Cancer Trial Database for Biomarker Study in Pancreatic Neuroendocrine Tumours
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Trial Identification
Brief Title: Biomarker Study in Pancreatic Neuroendocrine Tumours
Official Title: Prospective Longitudinal Biomarker Study in Pancreatic Neuroendocrine Tumours
Study ID: NCT03130205
Conditions
Study Description
Brief Summary: The biology of pancreatic neuroendocrine tumors can change during the disease course. This evolution of disease can manifest through increases in tumor proliferation rate, resistance to medical therapy and/or a change in tumor hormone secretion. This study aims to characterize how the biology of pancreatic neuroendocrine tumors change over time, measured by; patient symptoms, biochemistry, contrast enhanced computed tomography, FDG-PET and core needle biopsy with histopathological analysis (Ki67 index and tumor cell differentiation). Uptake on 18F-FDG-PET will be correlated directly to tumor cell proliferation rate. Fraction of patients with spatial heterogeneity in FDG uptake as well as metachronous changes in all collected data will be documented. Biomaterial from whole blood and core needle biopsies will be characterized on the molecular level, and those findings will be integrated to the above specified clinical parameters.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Akademiska Sjukhuset, Uppsala, , Sweden
Contact Details
Name: Barbro Eriksson, MD PhD
Affiliation: Akademiska Sjukhuset, Uppsala
Role: PRINCIPAL_INVESTIGATOR
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