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Spots Global Cancer Trial Database for Selective Intra-arterial Injection of PRRT in Neuroendocrine Tumor Patients With Liver Metastases

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Trial Identification

Brief Title: Selective Intra-arterial Injection of PRRT in Neuroendocrine Tumor Patients With Liver Metastases

Official Title: Selective Intra-arterial Injection of Peptide Receptor Radionuclide Therapy (PRRT) in Neuroendocrine Tumor Patients With Liver Metastases

Study ID: NCT03724409

Interventions

[90]Y-DOTATOC

Study Description

Brief Summary: This is a safety study to determine the phase 1 starting dose of \[90\]Yttrium-DOTATOC when it is administered intravenously for patients with neuroendocrine tumors that have spread to the liver.

Detailed Description: \[90\]Yttrium-DOTATOC is a radioactive drug used for peptide receptor radionuclide therapy (PRRT). In other studies, 90Y-DOTATOC has been administered through a vein (IV) to target somatostatin receptor positive tumor tissue. The DOTATOC identifies the tumor through the somatostatin receptor and links to it, attaching the radioactive molecule 90Yttrium to the malignant cell. This study expands the initial work to examine if administering the drug 90Y-DOTATOC directly to the liver is safe for patients with neuroendocrine tumors whose disease has spread to their tumor. We don't know how of the 90Y-DOTATOC is safe to administer. We want to learn what the maximum safe dose is and what the side effects are related to that dose.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

The Holden Comprehensive Cancer Center, Iowa City, Iowa, United States

Contact Details

Name: M. S O'Dorisio, MD, PhD

Affiliation: University of Iowa

Role: STUDY_CHAIR

Name: Sandeep Laroia, MD

Affiliation: University of Iowa

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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