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Spots Global Cancer Trial Database for Interventions for Reading Disabilities in NF1

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Trial Identification

Brief Title: Interventions for Reading Disabilities in NF1

Official Title: Neurobiology and Treatment of Reading Disability in NF1

Study ID: NCT02964884

Study Description

Brief Summary: Neurofibromatosis Type 1 (NF1) is a common genetic disorder that is associated with a four times greater risk of learning disabilities, including reading disabilities, and a deficiency of neurofibromin - a protein important in a signaling pathway that regulates learning and memory. Our previous work (NS49096) demonstrated that school-age children with NF+RD can respond to standard phonologically-based reading tutoring originally developed to treat reading disability in the general population. Combining our work with that by other researchers suggesting that a medication (Lovastatin) may counteract the effects of the deficient neurofibromin, and possibly ameliorate learning disabilities in NF1, the investigator propose to examine the synergistic effects of medication plus reading tutoring.

Detailed Description: Neurofibromitosis Type 1 (NF1) is a common autosomal dominant neurocutaneous syndrome. The most common concern of NF1 is learning disabilities (LDs). Approximately half of children with NF1 have LDs, the most common of which are reading disabilities (RDs).The purpose of this research is to gain a deeper understanding of the characteristics and treatment of RDs in NF1. The Investigator will evaluate four different groups (see list below) to determine if there are differential outcomes in these groups of children with NF+RD. The first two groups will consist of NF1 patients, and the second two groups will consist of participants with RDs but without NF1. 1. Reading tutoring program and a medication called Lovastatin (NF1 patients) 2. Reading tutoring program and no Lovastatin (placebo) (NF1 patients) 3. Reading tutoring program (RD participants) 4. Other Academic "Sham" tutoring (eligible to receive reading tutoring after study participation is complete) (RD participants)

Eligibility

Minimum Age: 8 Years

Eligible Ages: CHILD, ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Vanderbilt University, Nashville, Tennessee, United States

Contact Details

Name: Laurie Cutting, PhD

Affiliation: Vanderbilt University Medical Center

Role: PRINCIPAL_INVESTIGATOR

Name: Sheryl L. Rimrodt-Frierson, MD

Affiliation: Vanderbilt University Medical Center

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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