Spots Global Cancer Trial Database for The Utility of Multiplex PCR for Detection of DNA in Neutropenic Patients With Hematological Malignancies
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Trial Identification
Brief Title: The Utility of Multiplex PCR for Detection of DNA in Neutropenic Patients With Hematological Malignancies
Official Title: Obtaining Early Diagnosis and Prognosis in Urgent Sepsis (OEDIPUS) Study
Study ID: NCT01669005
Conditions
Interventions
Study Description
Brief Summary: Objectives: Invasive infections are the leading cause of morbidity and mortality in patients treated for hematological malignancies. Blood cultures are often negative in neutropenic patients because of low-burden of organisms, previous antibiotic therapy or non-infectious reason of fever. More rapid, accurate and sensitive diagnostic tools are needed. Hypothesis: Multiplex real-time PCR may detect microbial DNA in neutropenic patients before febrile episode. To investigate this hypothesis, EDTA-blood was routinely collected for multiplex PCR at admission and 3x/week thereafter until discharge or recovery from neutropenia
Detailed Description:
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Contact Details
Name: Andrej Trampuz, MD
Affiliation: University Hospital Lausanne, Switzerland
Role: STUDY_DIRECTOR
Name: Christina Orasch, MD
Affiliation: University Hospital Lausanne, Switzerland
Role: PRINCIPAL_INVESTIGATOR
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