Spots Global Cancer Trial Database for Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma
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Trial Identification
Brief Title: Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma
Official Title: Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma- A Randomized Multicenter Trial
Study ID: NCT01805453
Conditions
Study Description
Brief Summary: To assess the efficacy of an Angiotensin-II inhibitor (Losartan) to reduce peritumoral edema in newly diagnosed glioblastoma patients.
Detailed Description: Multicentre, randomized (1:1), double blinded trial:- Arm A: Standard of care (Radiotherapy with concomitant temozolomide followed by monthly cures of temozolomide ) + Losartan 50mg\*2/day until the halting for any reason - Arm B: Standard of care (Radiotherapy with concomitant temozolomide followed by monthly cures of temozolomide + Placebo 2/day until the halting for any reason.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Neurology Department - Avicenne Hospital, Bobigny, , France
Contact Details
Name: Antoine CARPENTIER, MD, PhD
Affiliation: Assistance Publique - Hôpitaux de Paris
Role: PRINCIPAL_INVESTIGATOR
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