Spots Global Cancer Trial Database for Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma

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Trial Identification

Brief Title: Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma

Official Title: A Phase 1 Study of Combination Drug Therapy Based on Personalized Cancer Stem Cell (CSC) High-Throughput Drug Screening (HTS) With Standard of Care for Newly Diagnosed Glioblastoma

Study ID: NCT05380349

Conditions

Newly Diagnosed Glioblastoma

Interventions

combinations of up to 3 FDA approved drugs from a panel of compounds

Study Description

Brief Summary: Proposed treatment of subjects with newly diagnosed glioblastoma with novel personalized drug regimens identified to be effective in vitro using cancer stem cells derived from their individual tumors, alongside standard of care radiation and TMZ.

Detailed Description: A panel of FDA approved drugs will be tested by high throughput screening, which is CLIA certified allowing for clinical decisions based on the results, to identify a combination of up to 3 drug candidates for treating individual patients. Lead candidates will be evaluated by pharmacists and a team of physicians, to confirm that prescribed drugs do not utilize pharmacological/ metabolic pathways that are known to increase the likelihood of toxicity, prior to initiating treatment. Investigational drug therapy, targeting CSCs, will be initiated alongside standard of care chemoradiation with TMZ.