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Brief Title: An Investigational Immuno-Therapy Study to Determine the Safety and Effectiveness of Nivolumab and Daratumumab in Patients With Multiple Myeloma
Official Title: Multiple Phase 1/2 Cohorts of Nivolumab Monotherapy or Nivolumab Combination Regimens Across Relapsed/Refractory Hematologic Malignancies
Study ID: NCT01592370
Brief Summary: The purpose of this study is to determine the side effects of treatment of the combination of nivolumab and daratumumab in participants with relapsed/refractory multiple myeloma.
Detailed Description: NOTE: Currently, this study is only open to nivolumab+daratumumab vs daratumumab monotherapy in multiple myeloma patients.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Local Institution - 0035, Clovis, California, United States
Division Of Hematology & Oncology Ctr. For Health Sciences, Los Angeles, California, United States
Local Institution - 0012, Los Angeles, California, United States
Local Institution - 0017, Aurora, Colorado, United States
Yale University School Of Medicine, New Haven, Connecticut, United States
Local Institution - 0023, Orlando, Florida, United States
Local Institution - 0037, Skokie, Illinois, United States
Local Institution - 0019, Indianapolis, Indiana, United States
Local Institution - 0018, Westwood, Kansas, United States
Local Institution - 0003, Baltimore, Maryland, United States
The Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Local Institution - 0009, Boston, Massachusetts, United States
Local Institution - 0015, Boston, Massachusetts, United States
Local Institution - 0011, Ann Arbor, Michigan, United States
University Of Michigan Health System, Ann Arbor, Michigan, United States
Local Institution - 0002, Rochester, Minnesota, United States
Mayo Clinic, Rochester, Minnesota, United States
Local Institution - 0033, Omaha, Nebraska, United States
John Theurer Cancer Center, Hackensack, New Jersey, United States
Local Institution - 0014, Hackensack, New Jersey, United States
Local Institution - 0001, New York, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Local Institution - 0028, Columbus, Ohio, United States
Local Institution - 0006, Portland, Oregon, United States
OHSU Center for Hematologic Malignancies, Portland, Oregon, United States
Abramson Cancer Center, Philadelphia, Pennsylvania, United States
Local Institution - 0007, Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Local Institution - 0004, Philadelphia, Pennsylvania, United States
Huntsman Cancer Institute At The Univ. Of Utah, Salt Lake City, Utah, United States
Local Institution - 0005, Salt Lake City, Utah, United States
Local Institution - 0045, Gent, , Belgium
Local Institution - 0047, Sint-Niklaas, , Belgium
Local Institution, Yvoir, , Belgium
Local Institution - 0043, Poitiers, Vienne, France
Local Institution - 0044, Nantes Cedex 1, , France
Local Institution - 0039, Athens, , Greece
Local Institution, Bologna, , Italy
Local Institution, Chorzow, , Poland
Local Institution - 0040, Poznan, , Poland
Local Institution - 0049, Warszawa, , Poland
Local Institution - 0042, Wroclaw, , Poland
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR