Spots Global Cancer Trial Database for An Open-Label, Multicenter Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab in Combination With Tiragolumab With or Without Atezolizumab in Participants With B-Cell Non-Hodgkin Lymphoma
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Trial Identification
Brief Title: An Open-Label, Multicenter Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab in Combination With Tiragolumab With or Without Atezolizumab in Participants With B-Cell Non-Hodgkin Lymphoma
Official Title: A Phase Ib/II Open-Label, Multicenter Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab in Combination With Tiragolumab With or Without Atezolizumab in Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma
Study ID: NCT05315713
Study Description
Brief Summary: This study will evaluate the safety, efficacy, and pharmacokinetics of mosunetuzumab in combination with tiragolumab, with or without atezolizumab, in participants with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma (FL) who have received at least two previous lines of systemic therapy.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
USC Norris Comprehensive Cancer Center, Los Angeles, California, United States
University of Michigan, Ann Arbor, Michigan, United States
Lifespan Cancer Institute, Providence, Rhode Island, United States
St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia
Eastern Health, Box Hill, Victoria, Australia
St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia
AZ Sint Jan Brugge Oostende AV, Brugge, , Belgium
Institut Jules Bordet, Bruxelles, , Belgium
AZ Groeninge, Kortrijk, , Belgium
CHU UCL Namur - Mont-Godinne, Yvoir, , Belgium
Tom Baker Cancer Centre-Calgary, Calgary, Alberta, Canada
Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Universitaet Duisburg-Essen, Essen, , Germany
Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
Royal Marsden Hospital - Institute of Cancer Research - Chelsea, London, , United Kingdom
Plymouth Hospitals NHS Trust - Derriford Hospital, Plymouth, , United Kingdom
Royal Marsden Hospital - Institute of Cancer Research - Sutton, Sutton, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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