Spots Global Cancer Trial Database for Radioimmunotherapy With 90Y-ibritumomab Tiuxetan as Part of a Dose Reduced Conditioning Regimen for Allogeneic Hematopoietic Cell Transplantation for the Treatment of Non-Hodgkin Lymphoma
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Trial Identification
Brief Title: Radioimmunotherapy With 90Y-ibritumomab Tiuxetan as Part of a Dose Reduced Conditioning Regimen for Allogeneic Hematopoietic Cell Transplantation for the Treatment of Non-Hodgkin Lymphoma
Official Title: Multicenter Phase I/II Study of Radioimmunotherapy With 90Y-ibritumomab Tiuxetan in a Nonmyeloablative Conditioning Regimen for Allogeneic Hematopoietic Cell Transplantation From HLA-identical Donors in Patients With Advanced Non-Hodgkin Lymphoma
Study ID: NCT00302757
Conditions
Study Description
Brief Summary: The study evaluates the additional use of radioimmunotherapy with a 90-Yttrium labeled monoclonal antibody targeting lymphoma cells in two dose reduced conditioning regimens for allogeneic hematopoietic cell transplantation from human leukocyte antigen (HLA)-identical donors. Radioimmunotherapy should allow an increased anti-lymphoma effect of the conditioning while the allogeneic grafts may confer potent graft versus lymphoma effects and rescue from potential hematopoietic side effects of the radioimmunotherapy. The study evaluates the feasibility and toxicity of such approach and will also analyze disease response and survival of the patients treated.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Medical Center Charite Benjamin Franklin, Berlin, , Germany
University of Dresden Medical Center, Dresden, , Germany
Center for Marrow Transplantation, University of Essen, Essen, , Germany
Medical Center University of Goettingen, Goettingen, , Germany
Medical Center University of Hannover, Hannover, , Germany
Medical Center University of Leipzig, Leipzig, , Germany
Medical Center University of Muenster, Muenster, , Germany
South West German Cancer Center, University of Tuebingen Medical Center, Tuebingen, , Germany
Medical Center University of Ulm, Ulm, , Germany
Stiftung Deutsche Klinik für Diagnostik GmbH, Wiesbaden, , Germany
University of Wuerzburg Medical Center, Wuerzburg, , Germany
Contact Details
Name: Wolfgang A Bethge, MD
Affiliation: Medical Center University of Tuebingen
Role: PRINCIPAL_INVESTIGATOR
Name: Donald Bunjes, MD
Affiliation: Medical Center University of Ulm
Role: PRINCIPAL_INVESTIGATOR
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