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Brief Title: Skin Cancer Prevention With Nicotinamide in Transplant Recipients - Pilot Trial
Official Title: Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients: A Pilot, Placebo-controlled, Randomized Trial
Study ID: NCT03769285
Brief Summary: A common long-term side effect of anti-rejection (immunosuppressant) medications is skin cancer. This pilot clinical trial evaluates the feasibility of conducting a larger pivotal trial to examine the efficacy and safety of nicotinamide for prevention of keratinocyte carcinoma in solid organ transplant recipients. This pilot trial will transition into the pivotal trial if all feasibility targets are met.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
Name: An-Wen Chan, MD DPhil
Affiliation: Women's College Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Joseph Kim, MD PhD
Affiliation: University Health Network, Toronto
Role: PRINCIPAL_INVESTIGATOR