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Brief Title: En Bloc Transurethral Resection of Non-muscle Invasive Bladder Cancer
Official Title: En Bloc Transurethral Resection of Non-muscle Invasive Bladder Cancer
Study ID: NCT05223491
Brief Summary: Aim: To compare the surgical method of En Bloc resection to the conventional transurethral resection of non-muscle invasive bladder cancer (NMIBC) in terms of complete removal of tumour, specimen quality, and pathological certainty. Background: NMIBC is a common disease with a 5-year recurrence rate reported as high as 64%. The cornerstone in the treatment of NMIBC is transurethral resection (TURB) where the tumour is dissected in pieces, removed from the bladder, and pathologically examined for potential muscle invasion. As the tumour is fragmented before removal, the method violates basic oncological principles and compromises pathological examination. Hence, TURB is possibly part of the mechanism causing recurrences. En Bloc resection (EBR), where the tumour is removed in toto, can potentially overcome the flaws of conventional TURB, but large randomized trials are needed. Methods: This project will be a multicentre randomised controlled clinical trial comparing EBR to conventional TURB. Patients with suspected NMIBC tumours with largest tumour diameter ≥1cm and ≤6cm will be randomised to either the intervention group, thus undergoing EBR, or the control group, undergoing conventional TURB. The investigators intend to include 220 patients in total, 110 patients in each group. The RCT will be initiated in 2022. Perspectives: If EBR can be shown to remove bladder tumours with better pathological quality and certainty, this could potentially spare patients from undergoing surgeries in the future, thereby reducing costs for both patients and society.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Department of Urology, Aalborg University Hospital, Aalborg, , Denmark
Department of Urology, Aarhus University Hospital, Aarhus, , Denmark
Department of Urology, Herlev Hospital, Herlev, , Denmark
Department of Urology, Regional Hospital Gødstrup, Holstebro, , Denmark
Department of Urology, Odense University Hospital, Odense, , Denmark
Department of Urology, Zealand University Hospital, Roskilde, , Denmark
Urological Center, Paula Stradina Clinical University Hospital, Riga, , Latvia
Department of Urology, Vestfold Hospital, Tønsberg, , Norway