Spots Global Cancer Trial Database for A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer
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Trial Identification
Brief Title: A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer
Official Title: A Phase II/III, Randomized, Double-Blind, Placebo-Controlled Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Patients With Previously Untreated Advanced Non-Squamous Non-Small-Cell Lung Cancer
Study ID: NCT04619797
Conditions
Study Description
Brief Summary: The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin (Arm A) compared with placebo in combination with pembrolizumab plus pemetrexed and carboplatin/cisplatin (Arm B) in participants with previously untreated, locally advanced unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC). Eligible participants will be randomized in a 1:1 ratio to receive one of the following treatment regimens during the induction phase: * Arm A: Tiragolumab plus atezolizumab plus pemetrexed and carboplatin or cisplatin * Arm B: Placebo plus pembrolizumab plus pemetrexed and carboplatin or cisplatin Following the induction phase, participants will continue maintenance therapy with either tiragolumab in combination with atezolizumab and pemetrexed (Arm A) or placebo in combination with pembrolizumab and pemetrexed (Arm B).
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
UCLA, Los Angeles, California, United States
Torrance Memorial Physician Network/Cancer Care, Torrance, California, United States
PIH Health Whittier Hospital; NC, Whittier, California, United States
SCRI Florida Cancer Specialists South, Fort Myers, Florida, United States
Advent Health Orlando, Orlando, Florida, United States
SCRI Florida Cancer Specialists North; Research Office North Region., Saint Petersburg, Florida, United States
Northwest Georgia Oncology Centers PC - Marietta, Marietta, Georgia, United States
Fort Wayne Medical Oncology and Hematology, Inc, Fort Wayne, Indiana, United States
Cancer Center of Kansas, Wichita, Kansas, United States
Baptist Health Lexington, Lexington, Kentucky, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Tennessee Oncology Chattanooga, Chattanooga, Tennessee, United States
Sarah Cannon Research Institute / Tennessee Oncology, Nashville, Tennessee, United States
Inova Schar Cancer Institute; Inova Schar Cancer Institute Infusion Pharmacy, Fairfax, Virginia, United States
Onze Lieve Vrouwziekenhuis Aalst, Aalst, , Belgium
Cliniques Universitaires St-Luc, Bruxelles, , Belgium
CHU UCL Mont-Godinne, Mont-godinne, , Belgium
Vitaz, Sint Niklaas, , Belgium
Crio - Centro Regional Integrado de Oncologia, Fortaleza, CE, Brazil
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijui, RS, Brazil
Hospital das Clinicas - UFRGS, Porto Alegre, RS, Brazil
Hospital Nossa Senhora da Conceicao, Porto Alegre, RS, Brazil
Hospital de Cancer de Barretos, Barretos, SP, Brazil
Cross Cancer Institute, Edmonton, Alberta, Canada
Royal Victoria Regional Health Centre, Barrie, Ontario, Canada
Victoria Hospital - London Health Sciences Centre, London, Ontario, Canada
Lakeridge Health Oshawa, Oshawa, Ontario, Canada
Sault Area Hospital; Algoma District Cancer Program, Sault Ste. Marie, Ontario, Canada
Universite de Montreal - Hopital Maisonneuve-Rosemont, Montreal, Quebec, Canada
Beijing Cancer Hospital, Beijing, , China
Jilin Cancer Hospital, Changchun, , China
Xiangya Hospital Central South University, Changsha City, , China
Changzhou First People's Hospital; Oncology, Changzhou, , China
Affiliated Hospital of Chengde Medical University, Chengde City, , China
Sichuan Cancer Hospital, Chengdu City, , China
West China Hospital - Sichuan University, Chengdu City, , China
Dongguan People's Hospital, Dongguan, , China
Anhui Provincial Hospital; Respiratory Department, Hefei, , China
Jinan Central Hospital, Jinan City, , China
Linyishi Cancer Hospital, Linyi City, , China
Pingxiang People Hospital, Pingxiang City, , China
Qingdao Central Hospital; Department of Respiratory and Critical Care Medicine, Qingdao City, , China
Weifang People's Hospital, Weifang City, , China
Hubei Cancer Hospital, Wuhan, , China
The First Affiliated Hospital of Xian Jiao Tong University, Xi'an City, , China
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang City, , China
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, , China
Rigshospitalet; Onkologisk Klinik, København Ø, , Denmark
Odense Universitetshospital, Onkologisk Afdeling R, Odense C, , Denmark
Sjællands Universitetshospital, Roskilde; Klinisk Onkologisk Afdeling og Palliativ Enhed, Roskilde, , Denmark
Institut Bergonie; Pneumology, Bordeaux, , France
Hopital Nord; Pneumologie, Marseille cedex 20, , France
Hopital de Pontchaillou; Service de Pneumologie, Rennes, , France
CHU Strasbourg - Nouvel Hopital Civil, Strasbourg, , France
CHU de Toulouse - Hôpital Larrey; Service de pneumologie et oncologie pneumologique, Toulouse cedex 9, , France
Helios Klinikum Emil von Behring GmbH, Berlin, , Germany
Klinikum Chemnitz gGmbH, Chemnitz, , Germany
St. Vincentius Kliniken Karlsruhe, Karlsruhe, , Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Medizinische Klinik, Pneumologie, Mainz, , Germany
Klinikum der Philipps-Universität Marburg, Marburg, , Germany
Hong Kong United Oncology Centre, Hong Kong, , Hong Kong
Queen Mary Hospital; Dept. of Clinical Oncology, Hong Kong, , Hong Kong
Queen Mary Hospital; Medicine & Respiratory, Hong Kong, , Hong Kong
Tuen Mun Hospital; Clinical Onc, Hong Kong, , Hong Kong
Prince of Wales Hospital; Department of Clinical Onocology, Shatin, , Hong Kong
Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica, Bologna, Emilia-Romagna, Italy
Centro Di Riferimento Oncologico; Struttura Operativa Complessa Di Oncologia Medica B, Aviano, Friuli-Venezia Giulia, Italy
A.O. Villa Scassi; Oncologia Medica, Genova, Liguria, Italy
Asst Papa Giovanni XXIII; Oncologia Medica, Bergamo, Lombardia, Italy
ASST Spedali Civili di Brescia, Brescia, Lombardia, Italy
Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1, Firenze, Toscana, Italy
Kyushu University Hospital, Fukuoka, , Japan
Kurume University Hospital, Fukuoka, , Japan
Hiroshima University Hospital, Hiroshima, , Japan
Takarazuka City Hospital, Hyogo, , Japan
University Hospital Kyoto Prefectural University of Medicine, Kyoto, , Japan
Sendai Kousei Hospital, Miyagi, , Japan
Osaka International Cancer Institute, Osaka, , Japan
Kansai Medical University Hospital, Osaka, , Japan
Kindai University Hospital, Osaka, , Japan
NHO Kinki Chuo Chest Medical Center, Osaka, , Japan
Saitama Cancer Center, Saitama, , Japan
The Cancer Institute Hospital of JFCR, Tokyo, , Japan
Tokyo Medical University Hachioji Medical Center, Tokyo, , Japan
Wakayama Medical University Hospital, Wakayama, , Japan
Kosin University Gospel Hospital, Busan, , Korea, Republic of
Kyungpook National University Chilgok Hospital, Daegu, , Korea, Republic of
Chungnam National University Hospital, Daejeon, , Korea, Republic of
St. Vincent's Hospital, Gyeonggi-do, , Korea, Republic of
Samsung Changwon Hospital, Gyeongsangnam-do, , Korea, Republic of
Seoul National University Hospital, Seoul, , Korea, Republic of
Kangbuk Samsung Hospital, Seoul, , Korea, Republic of
Severance Hospital, Yonsei University Health System, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Seoul St Mary's Hospital, Seoul, , Korea, Republic of
Health Pharma Professional Research, Cdmx, Mexico CITY (federal District), Mexico
Cuidados oncologicos, Querétaro, Queretaro, Mexico
Oncologico Potosino, San Luis Potosí, SAN LUIS Potosi, Mexico
ARKE Estudios Clínicos S.A. de C.V., Ciudad de México, , Mexico
Auckland City Hospital, Cancer and Blood Research, Auckland, , New Zealand
Waikato Hospital - Cancer and Blood Research Trials Unit; Regional Cancer Centre, Hamilton, , New Zealand
Palmerston North Hospital, Palmerston North, , New Zealand
Tauranga Hospital, Clinical Trials Unit; BOP Clinical School, Tauranga, , New Zealand
Centrum Terapii Wspolczesnej J.M.Jasnorzewska Spolka Komandytowo-Akcyjna, ?ód?, , Poland
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie; Oddzial onkologii z pododdzialem chemioterapii, Olsztyn, , Poland
ICO L'Hospitalet; Servicio de oncologia medica, L'Hospitalet de Llobregat, Barcelona, Spain
Hospital Son Llatzer; Servicio de Oncologia, Palma de Mallorca, Islas Baleares, Spain
Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Oncologia, A Coruña, LA Coruña, Spain
Complejo Hospitalario Universitario Insular?Materno Infantil; Servicio de Oncologia, Las Palmas de Gran Canaria, LAS Palmas, Spain
Hospital del Mar; Servicio de Oncologia, Barcelona, , Spain
Hospital Clinic Barcelona; Servicio de oncologia, Barcelona, , Spain
Hospital Lucus Augusti; Servicio de Oncologia, Lugo, , Spain
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario La Paz; Servicio de Oncologia, Madrid, , Spain
Hospital Univ. Nuestra Señora de Valme; Servicio de Oncologia, Sevilla, , Spain
Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia, Valencia, , Spain
Kantonsspital Aarau, Aarau, , Switzerland
Kantonsspital Graubünden Medizin Onkologie; Onkologie und Hämatologie, Chur, , Switzerland
UniversitätsSpital Zürich; Zentrum für Hämatologie und Onkologie, Klinik für Onkologie, Zürich, , Switzerland
Changhua Christian Hospital, Chang Hua, , Taiwan
China Medical University Hospital, Taichung, , Taiwan
Taipei Veterans General Hospital, Taipei City, , Taiwan
Vajira Hospital, Bangkok, , Thailand
Chulalongkorn Hospital; Medical Oncology, Bangkok, , Thailand
Pramongkutklao Hospital; Medicine - Medical Oncology Unit, Bangkok, , Thailand
Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology, Bangkok, , Thailand
Maharaj Nakorn Chiang Mai Hospital; Department of Medicine, ChiangMai, , Thailand
Songklanagarind Hospital; Department of Internal Medicine, Division of Respiratory, Songkhla, , Thailand
Adana Baskent University Medical Faculty; Oncology, Adana, , Turkey
Ankara Bilkent City Hospital, Ankara, , Turkey
Liv Hospital Ankara; Medical Oncology, Ankara, , Turkey
Dicle University Faculty of Medicine, Diyarbakir, , Turkey
Trakya University Medical Faculty, Edirne, , Turkey
Istanbul University Cerrahpasa Medical Faculty, Istanbul, , Turkey
Medeniyet University Goztepe Training and Research Hospital., Kadiköy, , Turkey
Royal Cornwall Hospital; Dept of Clinical Oncology, Cornwall, , United Kingdom
Castle Hill Hospital; The Queen's Centre for Oncology & Haematology, Hull, , United Kingdom
Barts & London School of Med; Medical Oncology, London, , United Kingdom
Guy'S Hospital; Oncology Unit, London, , United Kingdom
Christie Hospital Nhs Trust; Medical Oncology, Manchester, , United Kingdom
Nottingham City Hospital, Nottingham, , United Kingdom
New Cross Hospital, Wolverhampton, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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