Spots Global Cancer Trial Database for A Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Participants With Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC)
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Trial Identification
Brief Title: A Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Participants With Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer (NSCLC)
Official Title: A Phase III, Open-Label, Randomized Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Patients With Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer Who Have Not Progressed After Concurrent Platinum-Based Chemoradiation
Study ID: NCT04513925
Conditions
Study Description
Brief Summary: The purpose of this study is to evaluate the efficacy and safety of atezolizumab in combination with tiragolumab compared with durvalumab in participants with locally advanced, unresectable Stage III non-small cell lung cancer (NSCLC) who have received at least two cycles of concurrent platinum-based chemoradiotherapy (CRT) and have not had radiographic disease progression.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Banner MD Anderson Cancer Center, Gilbert, Arizona, United States
Arizona Clinical Research Center, Inc, Tucson, Arizona, United States
Genesis Cancer and Blood Institute, Hot Springs, Arkansas, United States
Stanford University, Palo Alto, California, United States
Florida Cancer Specialists; Department of Oncology, Fort Myers, Florida, United States
Woodlands Medical Specialists, P.A., Pensacola, Florida, United States
Cancer Care Centers of Brevard, Rockledge, Florida, United States
Florida Cancer Specialist, North Region, Saint Petersburg, Florida, United States
Northwest Georgia Oncology Centers PC - Marietta, Marietta, Georgia, United States
Illinois Cancer Care, Peoria, Illinois, United States
New England Cancer Specialists, Brunswick, Maine, United States
Southcoast Health System, Fairhaven, Massachusetts, United States
Minnesota Oncology Hematology, Saint Paul, Minnesota, United States
HCA Midwest Health, Kansas City, Missouri, United States
Cox Health Systems, Springfield, Missouri, United States
Optum Health Care, Las Vegas, Nevada, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
Titan Health Partners LLC, d/b/a Astera Cancer Care, East Brunswick, New Jersey, United States
San Juan Oncology Associates, Farmington, New Mexico, United States
New York Oncology Hematology,P.C.-Albany, Albany, New York, United States
Montefiore Medical Center, Bronx, New York, United States
Mount Sinai Medical Center, New York, New York, United States
Prisma Health ? Upstate, Greenville, South Carolina, United States
Tennessee Oncology Chattanooga, Chattanooga, Tennessee, United States
SCRI Oncology Partners, Nashville, Tennessee, United States
Virginia Cancer Specialists, Fairfax, Virginia, United States
Virginia Oncology Associates, Norfolk, Virginia, United States
Cemic; Oncologia Clinica, Buenos Aires, , Argentina
Hospital Britanico de Buenos Aires, Ciudad Autonoma Buenos Aires, , Argentina
Clinica Universitaria Reina Fabiola, Cordoba, , Argentina
Sanatorio Parque S.A., Rosario, , Argentina
Blacktown Hospital, Blacktown, New South Wales, Australia
Macarthur Cancer Therapy Centre, Campbelltown, New South Wales, Australia
St George Hospital; Cancer Care Centre, Kogarah, New South Wales, Australia
Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
Flinders Medical Centre, Bedford Park, South Australia, Australia
Fiona Stanley Hospital; FSH Cancer Centre Clinical Trials Unit, Bull Creek, Western Australia, Australia
Monash Health Translational Precinct; Clinical Trials Centre, Level 3, Victoria, , Australia
Tiroler Landeskrankenanstalten Ges.M.B.H.; Innere Medizin Abt. Für Hämatologie & Onkologie, Innsbruck, , Austria
Kepler Universitätskliniken GmbH - Med Campus III; Abt. für Lungenkrankheiten, Linz, , Austria
Klinik Penzing; Abteilung für Atemwegs- und Lungenkrankheiten, Wien, , Austria
GHdC Site Notre Dame, Charleroi, , Belgium
AZ Maria Middelares, Gent, , Belgium
Jessa Zkh (Campus Virga Jesse), Hasselt, , Belgium
Hospital Sao Rafael - HSR, Salvador, BA, Brazil
Crio - Centro Regional Integrado de Oncologia, Fortaleza, CE, Brazil
Centro Integrado de Oncologia de Curitiba, Curitiba, PR, Brazil
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijui, RS, Brazil
Hospital Sao Lucas - PUCRS, Porto Alegre, RS, Brazil
Hospital de Cancer de Barretos, Barretos, SP, Brazil
Hospital de Base de Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, SP, Brazil
BC Cancer ? Abbotsford, Abbotsford, British Columbia, Canada
BC Cancer - Victoria, Victoria, British Columbia, Canada
Royal Victoria Regional Health Centre; c/o Oncology Clinical Trials, Barrie, Ontario, Canada
William Osler Health System Brampton Civic Hospital, Brampton, Ontario, Canada
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Beijing Cancer Center; Renal Cancer And Melanoma Department., Beijing City, , China
Beijing Chest Hospital; Oncology Department, Beijing, , China
Jilin Cancer Hospital, Changchun, , China
Xiangya Hospital Central South University, Changsha City, , China
Changzhou Cancer hospital, Changzhou, , China
Sichuan Provincial Cancer Hospital, Chengdu, , China
Chongqing Cancer Hospital, Chongqing, , China
Fujian Medical University Union Hospital, Fuzhou City, , China
Fujian Provincial Cancer Hospital, Fuzhou City, , China
Cancer Center, Sun Yat-sen University of Medical Sciences; Department of Medical Oncology, Guangzhou City, , China
Hangzhou Cancer Hospital, Hangzhou City, , China
Sir Run Run Shaw Hospital Zhejiang University, Hangzhou City, , China
Shandong Cancer Hospital, Jinan, , China
Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University), Nanjing City, , China
Zhongda Hospital Affiliated to Southeast University, Nanjing, , China
The affiliated hospital of Qingdao university, Qingdao City, , China
Shanghai Chest Hospital, Shanghai, , China
Shanghai Pulmonary Hospital, Shanghai, , China
Cancer Hospital of Shantou University Medical College, Shantou, , China
Shanxi Provincial Cancer Hospital, Taiyuan, , China
Tianjin Cancer Hospital, Tianjin, , China
The 2nd School of Medicine, WMU, Wenzhou City, , China
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan City, , China
Hubei Cancer Hospital, Wuhan, , China
The First Affiliated Hospital of Xiamen University, Xiamen, , China
The Affiliated Hospital of Xuzhou Medical College, Xuzhou, , China
Henan Cancer Hospital, Zhengzhou, , China
CHU Angers, Angers, , France
CENTRE FRANCOIS BACLESSE; Oncologie- Pneumologie, Caen, , France
Hopital Nord AP-HM, Marseille, , France
Clinique Clémentville, Montpellier, , France
Hopital Robert Schuman; Pneumologie, Vantoux, , France
Institut Gustave Roussy; Pathologie Thoracique, Villejuif cedex, , France
Klinikum Braunschweig; Medizinische Klinik III; Klinik für Hämatologie und Onkologie, Braunschweig, , Germany
Universitaetsmedizin Goettingen; Abteilung Haematologie und Onkologie, Göttingen, , Germany
Thoraxklinik Heidelberg gGmbH, Heidelberg, , Germany
Klinikum Koeln-Merheim; Lungenklinik, Köln, , Germany
Klinikum Bogenhausen; Klinik für Pneumologie und Pneumologische Onkologie, München, , Germany
Universitätsklinikum Regensburg; Klinik und Poliklinik für Innere Medizin II, Pneumologie, Regensburg, , Germany
General Hospital "G.Papanikolaou"; Pulmonogy Clinic, Asvestochori, , Greece
Sotiria Hospital, Athens, , Greece
Univ General Hosp Heraklion; Medical Oncology, Heraklion, , Greece
Agioi Anargyroi Cancer Hospital; 2Nd Oncology Dept., Kifisia, , Greece
Pamela Youde Nethersole Eastern Hospital; Clinical Oncology, Hong Kong, , Hong Kong
Princess Margaret Hospital, Oncology; Department of Oncology, Hong Kong, , Hong Kong
Queen Elizabeth Hospital; Clinical Oncology, Hong Kong, , Hong Kong
Tuen Mun Hospital; Clinical Onc, Hong Kong, , Hong Kong
Queen Mary Hospital, Pokfulam, , Hong Kong
Pécsi Tudományegyetem; Klinikai Központ Onkoterápiás Intézet, Pécs, , Hungary
Szent Borbala Korhaz, Tatabánya, , Hungary
Tudogyogyintezet Torokbalint, Torokbalint, , Hungary
Soroka Medical Center; Oncology Dept, Beer Sheva, , Israel
Rambam Medical Center; Oncology, Haifa, , Israel
Shaare Zedek Medical Center; Oncology Dept, Jerusalem, , Israel
Rabin Medical Center; Oncology Dept, Petah Tikva, , Israel
Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale, Napoli, Campania, Italy
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola, Emilia-Romagna, Italy
Azienda Ospedaliero Universitaria di Parma, Parma, Emilia-Romagna, Italy
Policlinico Universitario Campus Biomedico; U.O.C. di Radioterapia Oncologica, Roma, Lazio, Italy
IRCCS Istituto Regina Elena (IFO); Oncologia Medica B, Roma, Lazio, Italy
IRCCS AOU San Martino - IST, Genova, Liguria, Italy
A.O. Spedali Civili Di Brescia-P.O. Spedali Civili; U.O. Radioterapia, Brescia, Lombardia, Italy
Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda), Milano, Lombardia, Italy
Fondazione IRCCS Policlinico San Matteo, Pavia, Lombardia, Italy
Azienda Ospedaliera Universitaria Pisana - Ospedale Cisanello; Dipartimento Cardio Toraco Vascolare, Pisa, Toscana, Italy
Azienda ULSS 8 Berica; Oncologia Medica - Ospedlae di Vicenza, Vicenza, Veneto, Italy
Aichi Cancer Center, Aichi, , Japan
National Cancer Center East, Chiba, , Japan
National Hospital Organization Himeji Medical Center, Hyogo, , Japan
Kitasato University Hospital, Kanagawa, , Japan
Kyoto University Hospital, Kyoto, , Japan
Sendai Kousei Hospital, Miyagi, , Japan
Niigata Cancer Center Hospital, Niigata, , Japan
Kindai University Hospital, Osaka, , Japan
Saitama Cancer Center, Saitama, , Japan
Shizuoka Cancer Center, Shizuoka, , Japan
National Cancer Center Hospital, Tokyo, , Japan
The Cancer Institute Hospital of JFCR, Tokyo, , Japan
Wakayama Medical University Hospital, Wakayama, , Japan
Chungbuk National University Hospital, Cheongju si, , Korea, Republic of
Kyungpook National University Chilgok Hospital, Daegu, , Korea, Republic of
National Cancer Center, Goyang-si, , Korea, Republic of
St. Vincent's Hospital, Gyeonggi-do, , Korea, Republic of
Ajou University Medical Center, Gyeonggi-do, , Korea, Republic of
Pusan National University Yangsan Hospital, Gyeongsangnam-do, , Korea, Republic of
Gachon University Gil Medical Center, Incheon, , Korea, Republic of
Chonnam National University Hwasun Hospital, Jeollanam-do, , Korea, Republic of
Seoul National University Bundang Hospital, Seongnam-si, , Korea, Republic of
Seoul National University Hospital, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Seoul St Mary's Hospital, Seoul, , Korea, Republic of
Korea University Guro Hospital, Seoul, , Korea, Republic of
Ulsan University Hosiptal, Ulsan, , Korea, Republic of
Meander Medisch Centrum, Amersfoort, , Netherlands
Amphia Ziekenhuis, Breda, , Netherlands
Medisch Centrum Haaglanden, locatie Antoniushove, Leidschendam, , Netherlands
Zuyderland Medisch Centrum - Sittard Geleen, Sittard-Geleen, , Netherlands
Auckland City Hospital, Cancer and Blood Research, Auckland, , New Zealand
Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii, Gdansk, , Poland
Szpital Kliniczny MSWiA z Warmi?sko-Mazurskim Centrum Onkologii; ZAK?.I O.KLINICZNY RADIOTERAPII, Olsztyn, , Poland
Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy; Oddzial Iii, Otwock, , Poland
Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad; Klinika Nowot.Pluca i Klatki Piers, Warszawa, , Poland
Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii; Oddz. Onkologii Klin. i Chemioterapii, Wroc?aw, , Poland
IPO de Coimbra; Servico de Oncologia Medica, Coimbra, , Portugal
Hospital da Luz; Departamento de Oncologia Medica, Lisboa, , Portugal
Hospital CUF Porto; Servico Pneumologia, Porto, , Portugal
IPO do Porto; Servico de Oncologia Medica, Porto, , Portugal
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia, Badalona, Barcelona, Spain
Hospital Provincial de Castellon; Servicio de Oncologia, Castellon de La Plana, Castellon, Spain
Hospital Son Llatzer; Servicio de Oncologia, Palma de Mallorca, Islas Baleares, Spain
Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Oncologia, A Coruña, LA Coruña, Spain
Hospital Universitari Vall d'Hebron; Oncology, Barcelona, , Spain
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario La Paz; Servicio de Oncologia, Madrid, , Spain
Hospital Regional Universitario Carlos Haya; Servicio de Oncologia, Malaga, , Spain
Hospital Universitario Virgen del Rocio; Servicio de Oncologia, Sevilla, , Spain
Hospital Univ. Nuestra Señora de Valme; Servicio de Oncologia, Sevilla, , Spain
China Medical University Hospital; Pulmonary and Critical Care Medicine, Taichung, , Taiwan
Taipei Veterans General Hospital; Chest Dept , Section of Thoracic Oncology, Taipei, , Taiwan
Vajira Hospital, Bangkok, , Thailand
Rajavithi Hospital; Division of Medical Oncology, Bangkok, , Thailand
Ramathibodi Hospital; Medicine/Oncology; Clinical Research Center, Bangkok, , Thailand
Songklanagarind Hospital; Department of Internal Medicine, Division of Respiratory, Songkhla, , Thailand
Adana Baskent University Medical Faculty; Oncology, Adana, , Turkey
Ankara University Medical Faculty; Medikal Onkoloji, Ankara, , Turkey
Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara, , Turkey
Gazi University Medical Faculty, Oncology Hospital, Ankara, , Turkey
Ege University Medical Faculty; Medical Oncology Department, Bornova, ?zm?r, , Turkey
Dicle University Faculty of Medicine, Diyarbakir, , Turkey
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi, Edirne, , Turkey
Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, , Turkey
Medipol University Medical Faculty; Oncology Department, Istanbul, , Turkey
Inonu University Faculty of Medicine Turgut Ozal Medical Center; Onkoloji, Elazig Yolu,, Malatya, , Turkey
Birmingham Heartlands Hospital, Birmingham, , United Kingdom
Addenbrooke's NHS Trust, Cambridge, , United Kingdom
Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
Calderdale & Huddersfield Nhs Trust; Oncology, Huddersfield, , United Kingdom
Leicester Royal Infirmary; Oncology Department, Leicester, , United Kingdom
Maidstone & Tonbridge Wells Hospital; Kent Oncology Center, Maidstone, , United Kingdom
Christie Foundation Trust, Manchester, , United Kingdom
Weston Park Hospital, Sheffield, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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