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Spots Global Cancer Trial Database for Clinical Trial of AMG510 in Stage III Unresectable NSCLC KRAS p.G12C Patients and Ineligible for Chemo-radiotherapy

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Trial Identification

Brief Title: Clinical Trial of AMG510 in Stage III Unresectable NSCLC KRAS p.G12C Patients and Ineligible for Chemo-radiotherapy

Official Title: Phase II Clinical Trial of AMG510 (Sotorasib) in Stage III Unresectable NSCLC KRAS p.G12C Patients and Medically Ineligible for Concurrent Chemo-radiotherapy

Study ID: NCT05398094

Interventions

Sotorasib

Study Description

Brief Summary: Open-label, non-randomised, exploratory, phase II, multi-centre clinical trial. 43 unresectable stage III (IIIA-N2, IIIB, IIIC) KRAS p.G12C non-small cell lung cancer patients will be enrolled in this trial to evaluate the efficacy of induction treatment of AMG510 (Sotorasib) plus AMG510 (Sotorasib) treatment post-induction as measured by Progression Free Survival at 12 months.

Detailed Description: This is an open-label, non-randomized, exploratory, phase II multi-centre clinical trial.The total sample size is 43 patients. The population to be included are unresectable stage III (IIIA-N2, IIIB, IIIC) KRAS p.G12C non-small cell lung cancer patients. Patients randomised will receive AMG510 (Sotorasib) 960mg once daily for 2 cycles (Q4W) in the induction phase and AMG510 (Sotorasib) 960 mg once daily (Q4W) in the treatment post-induction phase. Treatment post-induction phase only for patients with SD, PR or CR after induction treatment. This treatment will be administered until progression disease (PD), unacceptable toxicity, patient or physician's decision to discontinue or death. The primary objective is to assess the efficacy of induction treatment of AMG510 (Sotorasib) plus AMG510 (Sotorasib) treatment post-induction as measured by Progression Free Survival at 12 (PFS12) months according to Response Evaluation Criteria in Solid Tumors (RECIST) version PFS are defined as the time from inclusion until objective tumor progression or death. Patient accrual is expected to be completed within 5 years and a half, treatment is planned to extend for 1.5 years and the patients will be followed up for 2 years. The study will end once survival follow-up has concluded.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

ICO Badalona, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

Hospitalario Universitario A Coruña, A Coruña, La Coruña, Spain

Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain

Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain

Hospital de Son Espases, Palma De Mallorca, Mallorca, Spain

Hospital General Universitario de Alicante, Alicante, , Spain

Hospital Universitari Quiron Dexeus, Barcelona, , Spain

Hospital Universitari Vall d' Hebron, Barcelona, , Spain

Hospital Parc Taulí, Barcelona, , Spain

Hospital De Basurto, Bilbao, , Spain

ICO Girona, Hospital Josep Trueta, Girona, , Spain

Hospital Clínico San Cecilio De Granada, Granada, , Spain

Complejo Hospitalario De Jaén, Jaén, , Spain

Hospital Universitario Lucus Augusti, Lugo, , Spain

Hospital Clínico San Carlos, Madrid, , Spain

Hospital Universitario Fundación Jiménez Díaz, Madrid, , Spain

Hospital Universitari Son Llatzer, Palma De Mallorca, , Spain

Hospital Universitario Virgen Del Rocio, Sevilla, , Spain

Hospital General Universitario De Valencia, Valencia, , Spain

Hospital Universitario La Fe, Valencia, , Spain

Contact Details

Name: Mariano Provencio, MD

Affiliation: Fundación GECP President

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

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