Spots Global Cancer Trial Database for A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
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Trial Identification
Brief Title: A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
Official Title: A Phase Ib/II, Open-Label, Multicenter Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination With Other Anti-Cancer Therapies in Patients With Previously Untreated Advanced Or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
Study ID: NCT05789082
Conditions
Study Description
Brief Summary: The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and activity of divarasib combined with other anti-cancer therapies in participants with previously untreated, advanced or metastatic non-small cell lung cancer (NSCLC).
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Yale Cancer Center, New Haven, Connecticut, United States
NYU Langone Hospital - Long Island, Mineola, New York, United States
NYU Cancer Center; NYU Cancer Institute, New York, New York, United States
Hospital Britanico; Oncologia, Buenos Aires, , Argentina
Clinica Adventista Belgrano; Oncology, Ciudad Autonoma Buenos Aires, , Argentina
Centro Oncologico Riojano Integral (CORI), La Rioja, , Argentina
Concord Repatriation General Hospital; Concord Cancer Centre, Concord, New South Wales, Australia
Peter MacCallum Cancer Centre; Medical Oncology, Melbourne, Victoria, Australia
Alfred Health, Melbourne, Victoria, Australia
Cliniques Universitaires St-Luc, Bruxelles, , Belgium
Jessa Zkh (Campus Virga Jesse), Hasselt, , Belgium
Clinique Ste-Elisabeth, Namur, , Belgium
AZ Delta (Campus Rumbeke), Roeselare, , Belgium
Crio - Centro Regional Integrado de Oncologia, Fortaleza, CE, Brazil
Hospital Nossa Senhora da Conceicao, Porto Alegre, RS, Brazil
Hospital de Cancer de Barretos, Barretos, SP, Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, SP, Brazil
Princess Margaret Cancer Center, Toronto, Ontario, Canada
Jewish General Hospital, Montreal, Quebec, Canada
Hunan Cancer Hospital, Changsha CITY, , China
Harbin Medical University Cancer Hospital, Harbin, , China
Shanghai Pulmonary Hospital, Shanghai, , China
Rambam Medical Center; Oncology, Haifa, , Israel
Rabin MC; Davidof Center - Oncology Institute, Petach Tikva, , Israel
Tel Aviv Sourasky Medical Ctr; Oncology, Tel Aviv, , Israel
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Campania, Italy
Policlinico Universitario Agostino Gemelli IRCCS; UOS Fase 1, Roma, Lazio, Italy
A.O. UNIVERSITARIA S. LUIGI GONZAGA; Oncologia Medica, Orbassano, Piemonte, Italy
Pusan National University Hospital, Busan, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Korea University Guro Hospital, Seoul, , Korea, Republic of
NKI The Netherlands Cancer Institute, Amsterdam, , Netherlands
UMC St Radboud, Nijmegen, , Netherlands
Uniwersyteckie Centrum Kliniczne; Osrodek Badan Wczesnych Faz, Gda?sk, , Poland
Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II; Oddzia? Onkologiczny, Kraków, , Poland
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie; Oddzial onkologii z pododdzialem chemioterapii, Olsztyn, , Poland
ICO Badalona-H.U. Germans Trias i Pujol, Badalona, Barcelona, Spain
NEXT Oncology-Hospital Quironsalud Madrid, Pozuelo de Alarcon, Madrid, Spain
Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, , Spain
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario Virgen del Rocio; Servicio de Oncologia, Sevilla, , Spain
Sahlgrenska University Hospital; Sahlgrenska Clinical Trial unit / Department of Oncology, Göteborg, , Sweden
Universitätsspital Basel; Oncology - Klinische Forschung, Basel, , Switzerland
Inselspital Bern; Universitätsklinik für Medizinische Onkologie, Klinische Forschungseinheit, Bern, , Switzerland
National Cheng Kung University Hospital; Internal Medicine, North Dist., , Taiwan
Taichung Veterans General Hospital; Dept of Internal Medicine, Taichung, , Taiwan
National Taiwan Uni Hospital; Internal Medicine, Taipei, , Taiwan
Chang Gung Medical Foundation - Linkou; Chest Dept, Taoyuan, , Taiwan
Adana City Hospital, Medical Oncology, Adana, , Turkey
Ankara Bilkent City Hospital, Ankara, , Turkey
Koc University Hospital; Oncology, Istanbul, , Turkey
Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
Barts & London School of Med; Medical Oncology, London, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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