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Spots Global Cancer Trial Database for Imaging of T-cell Activation With [18F]F-AraG in Advanced Non Small Cell Lung Cancer

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Trial Identification

Brief Title: Imaging of T-cell Activation With [18F]F-AraG in Advanced Non Small Cell Lung Cancer

Official Title: Imaging of T-cell Activation With [18F]F-AraG in Advanced Non Small Cell Lung Cancer (NSCLC) Patients Undergoing PD-1/PD-L1 Directed Therapy

Study ID: NCT04726215

Interventions

[18F]F AraG

Study Description

Brief Summary: This is a pilot study using \[18F\]F AraG PET imaging to evaluate the immunological response to checkpoint inhibitor therapy (CkIT) in patients with advanced NSCLC tumors at multiple study sites. The main objectives of the study are to quantify the change in \[18F\]F AraG PET signal before and after CkIT therapy, and to correlate this change in \[18F\]F AraG PET signal with a radiographic response.

Detailed Description: Approximately 50 patients will undergo two research PET/CT scans with \[18F\]F AraG at two time points. Each patient will receive two 5 (+/-10%) mCi doses of \[18F\]F AraG, one for each imaging time point. Eligible subjects will undergo a pre-treatment \[18F\]F AraG PET/CT scan within 7 days prior to treatment, followed by treatment, and an on-treatment \[18F\]F AraG PET/CT within 7-14 days of treatment. Objectives: * Quantify \[18F\]F-AraG uptake in advanced NSCLC tumor (primary, nodal, and metastatic sites) at baseline and after 1 dose of anti-PD-1/PD-L1 therapy in patients treated with standard of care immunotherapy (as monotherapy or part of combination therapy). * Correlate change in \[18F\]F AraG uptake in tumor lesions with radiographic response.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Palo Alto Veterans Institute of Research, Palo Alto, California, United States

Sutter Cancer Center, Sacramento, California, United States

Stony Brook University, Stony Brook, New York, United States

Contact Details

Name: Deepak Behera, MD

Affiliation: CellSight Technologies, Inc.

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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