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Brief Title: A Study of Nivolumab and Ipilimumab Combined With Chemotherapy Compared to Chemotherapy Alone in First Line NSCLC
Official Title: A Phase 3, Randomized Study of Nivolumab Plus Ipilimumab in Combination With Chemotherapy vs Chemotherapy Alone as First Line Therapy in Stage IV Non-Small Cell Lung Cancer
Study ID: NCT03215706
Brief Summary: The purpose of this study is to determine whether Nivolumab, Ipilimumab combined with chemotherapy is more effective than chemotherapy by itself when treating stage IV NSCLC as the first treatment given for the disease
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Memorial Health Systems, Colorado Springs, Colorado, United States
Local Institution - 0044, Plainville, Connecticut, United States
Baptist MD Anderson Cancer Center, Jacksonville, Florida, United States
Local Institution - 0029, Marietta, Georgia, United States
Local Institution - 0091, Wichita, Kansas, United States
Local Institution - 0004, Lexington, Kentucky, United States
Henry Ford Health System, Detroit, Michigan, United States
Local Institution - 0058, Johnson City, New York, United States
Local Institution - 0098, Mineola, New York, United States
Local Institution - 0095, Columbus, Ohio, United States
Local Institution - 0006, Lancaster, Pennsylvania, United States
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
Local Institution - 0093, Pittsburgh, Pennsylvania, United States
Local Institution - 0094, Charleston, South Carolina, United States
Southwest Regional Cancer Clinic, Saint George, Utah, United States
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States
Local Institution - 0014, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Local Institution - 0028, Rio Cuarto, Cordoba, Argentina
Local Institution - 0026, Viedma, Rio Negro, Argentina
Local Institution - 0027, Rosario, Santa Fe, Argentina
Local Institution - 0030, Cordoba, , Argentina
Local Institution - 0086, Gosford, New South Wales, Australia
Local Institution - 0040, Bedford Park, South Australia, Australia
Local Institution - 0089, Box Hill, Victoria, Australia
Local Institution - 0036, Heidelberg, Victoria, Australia
Local Institution - 0078, Murdoch, Western Australia, Australia
Local Institution - 0002, Gilly, , Belgium
Local Institution - 0033, Leuven, , Belgium
Local Institution - 0001, Roeselare, , Belgium
Local Institution - 0068, Natal, RIO Grande DO Norte, Brazil
Local Institution - 0063, Ijui, Rio Grande Do Sul, Brazil
Local Institution - 0067, Porto Alegre, Rio Grande Do Sul, Brazil
Local Institution - 0069, Blumenau, Santa Catarina, Brazil
Local Institution - 0064, Barretos, Sao Paulo, Brazil
Local Institution - 0065, Sao Jose Do Rio Preto, Sao Paulo, Brazil
Local Institution - 0066, Rio De Janeiro, , Brazil
Local Institution - 0070, São Paulo, , Brazil
Local Institution - 0090, Montreal, Quebec, Canada
Local Institution - 0083, Montreal, Quebec, Canada
Local Institution - 0082, Montreal, Quebec, Canada
Local Institution - 0080, Rimouski, Quebec, Canada
Local Institution - 0084, Santiago, Metropolitana, Chile
Local Institution - 0059, Santiago, Región Metropolitana De Santiago, Chile
Local Institution - 0079, Vina Del Mar, Valparaiso, Chile
Local Institution - 0139, Beijing, BEI, China
Local Institution - 0146, Haikou, Hainan, China
Local Institution - 0148, Zhengzhou, Henan, China
Local Institution - 0120, Zhengzhou, Henan, China
Local Institution - 0144, Changsha, Hunan, China
Local Institution - 0106, Changchun, Jilin, China
Local Institution - 0108, Xi'an City, Shan3xi, China
Local Institution - 0110, Hangzhou, Zhejiang, China
Local Institution - 0111, Zhejiang, Zhejiang, China
Local Institution - 0113, Beijing, , China
Local Institution - 0112, Shanghai, , China
Local Institution - 0010, Bron, Rhone Alpes, France
Local Institution - 0009, Lyon Cedex08, Rhône-Alpes, France
Local Institution - 0013, Caen, , France
Local Institution - 0071, Lille Cedex, , France
Local Institution - 0012, Montpellier, , France
Local Institution - 0035, Nantes, , France
Local Institution - 0011, Paris Cedex 20, , France
Local Institution - 0097, Saint-Brieuc, , France
Local Institution - 0073, Berlin, , Germany
Local Institution - 0016, Gauting, , Germany
Local Institution - 0072, Grosshansdorf, , Germany
Local Institution - 0019, Hemer, , Germany
Local Institution - 0017, Immenhausen, , Germany
Local Institution - 0074, Magdeburg, , Germany
Local Institution - 0015, Muenchen, , Germany
Local Institution - 0018, Yes, , Germany
Local Institution - 0021, Dublin, , Ireland
Local Institution - 0020, Limerick, , Ireland
Ospedale San Luca, Lucca, , Italy
Ospedale San Raffaele, Milano, , Italy
Local Institution - 0043, Napoli, , Italy
Local Institution - 0101, Fukushima-shi, Fukushima, Japan
Local Institution - 0118, Maebashi-shi, Gunma, Japan
Local Institution - 0128, Ota-shi, Gunma, Japan
Local Institution - 0138, Hiroshima-shi, Hiroshima, Japan
Local Institution - 0137, Hiroshima-shi, Hiroshima, Japan
Local Institution - 0127, Sapporo-shi, Hokkaido, Japan
Local Institution - 0131, Akashi-shi, Hyogo, Japan
Local Institution - 0119, Himeji-shi, Hyogo, Japan
Local Institution - 0104, Kobe-shi, Hyogo, Japan
Local Institution - 0115, Kanazawa-shi, Ishikawa, Japan
Local Institution - 0100, Shiwa-gun, Iwate, Japan
Local Institution - 0129, Yokohama-shi, Kanagawa, Japan
Local Institution - 0114, Yokohama-Shi, Kanagawa, Japan
Local Institution - 0134, Yokohama-shi, Kanagawa, Japan
Local Institution - 0116, Niigata-shi, Niigata, Japan
Local Institution - 0136, Okayama-shi, Okayama, Japan
Local Institution - 0135, Habikino-shi, Osaka, Japan
Local Institution - 0103, Osaka-sayama-shi, Osaka, Japan
Local Institution - 0130, Osaka-shi, Osaka, Japan
Local Institution - 0102, Kitaadachi-gun, Saitama, Japan
Local Institution - 0132, Ube-shi, Yamaguchi, Japan
Local Institution - 0077, La Paz, BAJA Californa SUR, Mexico
Local Institution - 0061, Guadalajara, Jalisco, Mexico
Local Institution - 0075, Veracruz, Veracruz, , Mexico
Local Institution - 0087, Bydgoszcz, , Poland
Local Institution - 0022, Bytom, , Poland
Local Institution - 0085, Gdańsk, , Poland
Local Institution - 0034, Bucharest, , Romania
Local Institution - 0031, Cluj Napoca, , Romania
Local Institution - 0032, Craiova, , Romania
Local Institution - 0024, Moscow, , Russian Federation
Local Institution - 0025, St.petersburg, , Russian Federation
Local Institution - 0054, A Coruña, , Spain
Local Institution - 0053, Barcelona, , Spain
Local Institution - 0052, Madrid, , Spain
Local Institution - 0055, Malaga, , Spain
Local Institution - 0056, Valencia, , Spain
Local Institution - 0050, Guildford, , United Kingdom
Local Institution - 0049, London, , United Kingdom
Local Institution - 0048, Tauton, , United Kingdom
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR