Spots Global Cancer Trial Database for A Randomized Phase 2 Study of Atezolizumab (an Engineered Anti-PDL1 Antibody) Compared With Docetaxel in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Platinum Therapy - "POPLAR"
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Trial Identification
Brief Title: A Randomized Phase 2 Study of Atezolizumab (an Engineered Anti-PDL1 Antibody) Compared With Docetaxel in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Platinum Therapy - "POPLAR"
Official Title: A Phase II, Open-label, Multicenter, Randomized Study to Investigate the Efficacy and Safety of MPDL3280A (Anti-PD-L1 Antibody) Compared With Docetaxel in Patients With Non-Small Cell Lung Cancer After Platinum Failure
Study ID: NCT01903993
Conditions
Study Description
Brief Summary: This multicenter, open-label, randomized study will evaluate the efficacy and safety of Atezolizumab compared with docetaxel in participants with advanced or metastatic non-small cell lung cancer after platinum failure. Participants will be randomized to receive either Atezolizumab 1200 milligram (mg) intravenously every 3 weeks or docetaxel 75 milligram per meter square (mg/m\^2) intravenously every 3 weeks. Treatment with Atezolizumab may be continued as long as participants are experiencing clinical benefit as assessed by the investigator, i.e., in the absence of unacceptable toxicity or symptomatic deterioration attributed to disease progression.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Arizona Oncology Associates, PC - HOPE, Tucson, Arizona, United States
Genesis Cancer Center, Hot Springs, Arkansas, United States
Loma Linda University Medical Center, Loma Linda, California, United States
Kaiser Permanente - San Marcos, San Marcos, California, United States
Kaiser Permanente - Vallejo, Vallejo, California, United States
Innovative Clinical Research Institute, Whittier, California, United States
Rocky Mountain Cancer Centers - Colorado Springs (Circle), Lone Tree, Colorado, United States
Ocala Oncology Center, Ocala, Florida, United States
Georgia Cancer Specialists, Atlanta, Georgia, United States
Ingalls Memorial Hospital, Harvey, Illinois, United States
Illinois Cancer Care, Peoria, Illinois, United States
New England Cancer Specialists, Scarborough, Maine, United States
Karmanos Cancer Institute.., Detroit, Michigan, United States
Billings Clinic; Research Center, Billings, Montana, United States
Comprehensive Cancer Centers of Nevada - Eastern Avenue, Las Vegas, Nevada, United States
The Valley Hospital, Paramus, New Jersey, United States
New York Oncology Hematology, P.C., Albany, New York, United States
Broome Oncology - Binghamton, Binghamton, New York, United States
Willamette Valley Cancer Ctr - 520 Country Club, Eugene, Oregon, United States
Rhode Island Hospital, Providence, Rhode Island, United States
Center for Biomedical Research LLC, Knoxville, Tennessee, United States
Texas Oncology - South Austin, Austin, Texas, United States
Texas Oncology, P.A. - Fort Worth, Fort Worth, Texas, United States
Virginia Cancer Specialists, PC, Fairfax, Virginia, United States
Virginia Oncology Associates, Norfolk, Virginia, United States
Blue Ridge Cancer Care, Roanoke, Virginia, United States
Northwest Cancer Specialists - Vancouver, Vancouver, Washington, United States
Providence St. Mary Regional Cancer Center, Walla Walla, Washington, United States
Wenatchee Valley Hospital & Clinics, Wenatchee, Washington, United States
UZ Leuven Gasthuisberg, Leuven, , Belgium
Chr de La Citadelle, Liège, , Belgium
Cite de La Sante de Laval; Hemato-Oncologie, Laval, Quebec, Canada
McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology, Montreal, Quebec, Canada
Hopital Gabriel Montpied; Service de Pneumologie, Clermont-ferrand, , France
Hôpital Nord Michallon; Pneumologie, La Tronche, , France
Centre D'Oncologie de Gentilly; Oncology, Nancy, , France
Centre Hospitalier de Saint Brieuc - Hôpital Yves Le Foll; Pneumologie, St Brieuc, , France
Hopital Larrey; Pneumologie, Toulouse, , France
Asklepios-Fachkliniken Muenchen-Gauting; Onkologie, Gauting, , Germany
Krankenhaus Martha-Maria Halle-Doelau gGmbH; Klinik fuer Innere Medizin II, Halle, , Germany
Fachklinik für Lungenerkrankungen, Immenhausen, , Germany
Universitätsklinikum Regensburg; Klinik und Poliklinik für Innere Medizin II, Pneumologie, Regensburg, , Germany
Citta Ospedaliera; Divisione Oncologia Medica, Avellino, Campania, Italy
Irccs Ospedale San Raffaele;Oncologia Medica, Milano, Lombardia, Italy
National Cancer Center; Medical Oncology, Gyeonggi-do, , Korea, Republic of
Severance Hospital, Yonsei University Health System, Seoul, , Korea, Republic of
Samsung Medical Centre; Division of Hematology/Oncology, Seoul, , Korea, Republic of
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii, Gdansk, , Poland
Woj.Wielospecjalistyczne Centrum Onkologii i Traumatologii; Oddz.Hematologii Pododz.Chemioterapii, Lodz, , Poland
Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy; Oddzial Iii, Otwock, , Poland
Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie Klinika Nowotworów Piersi i Chirurgii, Warszawa, , Poland
Hospital Ramon y Cajal; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid, , Spain
Hospital La Paz, Madrid, , Spain
Hospital Universitario Miguel Servet; Servicio Oncologia, Zaragoza, , Spain
Universitetssjukhuset Linköping; Lungmedicinkliniken, Linköping, , Sweden
Chulalongkorn Hospital; Medical Oncology, Bangkok, , Thailand
Rajavithi Hospital; Division of Medical Oncology, Bangkok, , Thailand
Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology, Bangkok, , Thailand
Akdeniz University Medical Faculty; Medical Oncology Department, Antalya, , Turkey
Istanbul Uni Cerrahpasa Medical Faculty Hospital; Medical Oncology, Istanbul, , Turkey
Royal Free Hospital; Dept of Oncology, London, , United Kingdom
Guys and St Thomas NHS Foundation Trust, Guys Hospital, London, , United Kingdom
Charing Cross Hospital; Medical Oncology., London, , United Kingdom
Christie Hospital Nhs Trust; Medical Oncology, Manchester, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
Take Control of Your Skin and Body Changes Today.
Try out Spots for free, set up only takes 2 mins.
Join others from around the world:
