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Brief Title: A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Official Title: A Phase 3 Open-Label, Randomized, Controlled, Global Study of Telisotuzumab Vedotin (ABBV-399) Versus Docetaxel in Subjects With Previously Treated c-Met Overexpressing, EGFR Wildtype, Locally Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer
Study ID: NCT04928846
Brief Summary: Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. Non-small cell lung cancer (NSCLC) is a solid tumor, a disease in which cancer cells form in the tissues of the lung. The purpose of this study is to determine if telisotuzumab vedotin works better than docetaxel and to assess how safe telisotuzumab vedotin is in adult participants with NSCLC who have previously been treated. Change in disease activity and adverse events will be assessed. Telisotuzumab vedotin is an investigational drug being developed for the treatment of NSCLC. Participants will be randomly assigned a treatment of Teliso-V or Docetax at an 1:1 ratio. Each group receives intravenous (IV) infusion of telisotuzumab vedotin or IV infusion of docetaxel. Approximately 698 adult participants with c-Met overexpressing NSCLC will be enrolled in the study in approximately 250 sites worldwide. Participants will receive IV telisotuzumab vedotin every 2 weeks or docetaxel every 3 weeks until meeting study drug discontinuation criteria. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Mayo Clinic Arizona /ID# 255858, Phoenix, Arizona, United States
Yuma Regional Medical Center /ID# 253625, Yuma, Arizona, United States
City of Hope /ID# 243157, Duarte, California, United States
City of Hope - Huntington Beach /ID# 263143, Huntington Beach, California, United States
City of Hope Orange County Lennar Foundation Cancer Center /ID# 263144, Irvine, California, United States
City of Hope - Antelope Valley /ID# 263138, Lancaster, California, United States
The Oncology Institute of Hope and Innovation - DTLA /ID# 239774, Los Angeles, California, United States
University of California, Los Angeles /ID# 253954, Los Angeles, California, United States
Eisenhower Medical Center /ID# 233189, Rancho Mirage, California, United States
Mayo Clinic /ID# 254688, Jacksonville, Florida, United States
Ocala Oncology Florida Cancer Affiliates - Main /ID# 234228, Ocala, Florida, United States
Kaiser Permanente Moanalua Medical Center /ID# 238363, Honolulu, Hawaii, United States
Edward-Elmhurst Cancer Center /ID# 238552, Elmhurst, Illinois, United States
Springfield Clinic /ID# 262290, Springfield, Illinois, United States
Goshen Center for Cancer Care /ID# 257734, Goshen, Indiana, United States
Investigative Clinical Research of Indiana - Indianapolis /ID# 260468, Indianapolis, Indiana, United States
Baptist Health Lexington /ID# 252769, Lexington, Kentucky, United States
Trinity Health St. Joseph Mercy Ann Arbor /ID# 232190, Ypsilanti, Michigan, United States
Mayo Clinic - Rochester /ID# 252052, Rochester, Minnesota, United States
Hattiesburg Clinic /ID# 248033, Hattiesburg, Mississippi, United States
St. Luke's Hospital - Chesterfield /ID# 251688, Chesterfield, Missouri, United States
St. Luke's Hosp. of Kansas City /ID# 259940, Kansas City, Missouri, United States
Alliance for Multispecialty Research (AMR) - Kansas City /ID# 247567, Kansas City, Missouri, United States
Hulston Cancer Center /ID# 232226, Springfield, Missouri, United States
Intermountain Health - St Vincent Regional Hospital - Cancer Centers of Montana /ID# 253147, Billings, Montana, United States
Renown Medical Group - Oncology/Hematology /ID# 247942, Reno, Nevada, United States
Astera Cancer Care /ID# 257753, East Brunswick, New Jersey, United States
San Juan Oncology Associates /ID# 244387, Farmington, New Mexico, United States
Maimonides Medical Center /ID# 240783, Brooklyn, New York, United States
FirstHealth of the Carolinas- Speciality Center /ID# 241279, Pinehurst, North Carolina, United States
Genesis Cancer Care Center /ID# 239190, Zanesville, Ohio, United States
Medical University of South Carolina /ID# 251383, Charleston, South Carolina, United States
Avera Cancer Institute - Aberdeen /ID# 257759, Aberdeen, South Dakota, United States
Avera Cancer Institute /ID# 239635, Sioux Falls, South Dakota, United States
Community Cancer Trials of Utah - South Ogden /ID# 262829, Ogden, Utah, United States
Valley Medical Center /ID# 253950, Renton, Washington, United States
Medical Oncology Associates /ID# 247003, Spokane, Washington, United States
Centro Médico Austral /ID# 239860, Ciudad Autonoma Buenos Aires, Ciudad Autonoma De Buenos Aires, Argentina
Cenit /Id# 239880, Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Hospital Britanico de Buenos Aires /ID# 231495, Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Centro de Investigaciones Clinicas Clinica Viedma S.A. /ID# 232339, Viedma, Rio Negro, Argentina
Barwon Health /ID# 241920, Geelong, Victoria, Australia
Austin Health /ID# 247507, Heidelberg, Victoria, Australia
Ordensklinikum Linz GmbH Elisabethinen /ID# 240967, Linz, Oberoesterreich, Austria
Klinikum Wels-Grieskirchen GmbH /ID# 249000, Wels, Oberoesterreich, Austria
Landeskrankenhaus Feldkirch /ID# 250333, Feldkirch, Vorarlberg, Austria
Medizinische Universitaet Wien /ID# 230615, Vienna, Wien, Austria
Klinik Penzing /ID# 230700, Vienna, Wien, Austria
Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 232467, Salzburg, , Austria
Universitair Ziekenhuis Antwerpen /ID# 239971, Edegem, Antwerpen, Belgium
Grand Hopital de Charleroi /ID# 234178, Charleroi, Hainaut, Belgium
Hospital La Louviere Site Jolimont - Helora /ID# 246771, La Louvière, Hainaut, Belgium
CHU de Liège /ID# 246772, Liège, Liege, Belgium
Institut Jules Bordet /ID# 246770, Anderlecht, , Belgium
Algemeen Ziekenhuis klina /ID# 239853, Brasschaat, , Belgium
AZ Maria Middelares /ID# 246768, Gent, , Belgium
Jessa Ziekenhuis /ID# 246766, Hasselt, , Belgium
UCL Namur University Hospital, Site Sainte-Elisabeth /ID# 246769, Namur, , Belgium
Ensino e Terapia de Inovacao - Clinica AMO /ID# 231604, Salvador, Bahia, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alegre /ID# 233249, Porto Alegre, Rio Grande Do Sul, Brazil
Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 233247, Barretos, Sao Paulo, Brazil
Instituto Nacional de Cancer (INCA) /ID# 231509, Rio de Janeiro, , Brazil
Instituto D'or de Pesquisa e Ensino /ID# 233245, Rio de Janeiro, , Brazil
Instituto de Ensino e Pesquisas Sao Lucas /ID# 247417, Sao Paulo, , Brazil
Casa de Saúde Santa Marcelina /ID# 231605, Sao Paulo, , Brazil
University Multiprofile Hospital for Active Treatment Sofiamed /ID# 234108, Sofiya, Sofia, Bulgaria
Complex Oncology Center - Burgas /ID# 240532, Burgas, , Bulgaria
Complex Cancer Center Plovdiv /ID# 234106, Plovdiv, , Bulgaria
UMHAT Sveta Marina /ID# 234112, Varna, , Bulgaria
CISSS de la Monteregie /ID# 239081, Greenfield Park, Quebec, Canada
Clinica Universidad Catolica del Maule /ID# 231294, Talca, Maule, Chile
Icegclinic /Id# 231212, La Florida, Region Metropolitana De Santiago, Chile
Sociedad Prosalud Montes y Orlandi /ID# 231154, Providencia, Region Metropolitana De Santiago, Chile
Fundacion Arturo Lopez Perez /ID# 231151, Providencia, Region Metropolitana De Santiago, Chile
Sociedad Oncovida /ID# 231152, Providencia, Region Metropolitana De Santiago, Chile
Anhui Medical University - Anhui Chest Hospital /ID# 231899, Hefei, Anhui, China
Beijing Cancer Hospital /ID# 231923, Beijing, Beijing, China
Peking Union Medical College Hospital (East) - Dongdan Campus /ID# 233175, Beijing, Beijing, China
Beijing Chest Hospital, Capital Medical University /ID# 232202, Beijing, Beijing, China
The First Affiliated Hospital of Chongqing Medical University /ID# 251592, Chongqing, Chongqing, China
Fujian Provincial Cancer Hospital /ID# 243134, Fuzhou, Fujian, China
The First Affiliated Hospital of Xiamen University /ID# 242381, Xiamen, Fujian, China
The First Affiliated Hospital of Guangzhou Medical University /ID# 238591, Guangzhou, Guangdong, China
Cancer Hospital of Shantou University Medical College /ID# 242182, Shantou, Guangdong, China
Affiliated Hospital of Guangdong Medical College /ID# 233317, Zhanjiang, Guangdong, China
Affiliated Cancer Hospital of Guangxi Medical University /ID# 231855, Nanning, Guangxi, China
People's Hospital of Guizhou Province /ID# 243614, Guiyang, Guizhou, China
Affiliated Hospital of Hebei University /ID# 239586, Baoding, Hebei, China
Harbin Medical University Cancer Hospital /Id# 231941, Harbin, Heilongjiang, China
The First affiliated Hospital of Nanyang Medical College /ID# 244652, Nanyang, Henan, China
People's Hospital of Henan Province /ID# 242187, Zhengzhou, Henan, China
Henan Cancer Hospital /ID# 239577, Zhengzhou, Henan, China
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 231904, Wuhan, Hubei, China
Tongji Hospital Tongji Medical College of HUST /ID# 239575, Wuhan, Hubei, China
Hubei Cancer Hospital /ID# 240045, Wuhan, Hubei, China
Hunan Cancer Hospital /ID# 231943, Changsha, Hunan, China
The Affiliated Hospital of Inner Mongolia Medical University /ID# 242179, Huhehaote, Inner Mongolia, China
Nanjing Drum Tower Hospital /ID# 231791, Nanjing, Jiangsu, China
Nantong Tumor Hospital /ID# 232424, Nantong, Jiangsu, China
The First Affiliated Hospital of Nanchang University /ID# 231934, Nanchang, Jiangxi, China
The Second Affiliated Hospital of Nanchang University /ID# 231935, Nanchang, Jiangxi, China
Jilin Cancer Hospital /ID# 244702, Changchun, Jilin, China
The Second Affiliated Hospital of Dalian Medical University /ID# 239755, Dalian, Liaoning, China
The First Hospital of China Medical University /ID# 231924, Shenyang, Liaoning, China
The First Affiliated Hospital of Xi'an Jiaotong University /ID# 232023, Xian, Shaanxi, China
Jinan Central Hospital /ID# 231895, Jinan, Shandong, China
Shandong Cancer Hospital /ID# 251506, Jinan, Shandong, China
LinYi Cancer Hospital /ID# 239713, Linyi, Shandong, China
Shanghai Chest Hospital /ID# 231897, Shanghai, Shanghai, China
Shanxi Cancer Hospital /ID# 258674, Taiyuan, Shanxi, China
Sichuan Cancer Hospital /ID# 239707, Chengdu, Sichuan, China
West China Hospital, Sichuan University /ID# 233703, Chengdu, Sichuan, China
Tianjin Cancer Hospital /ID# 233176, Tianjin, Tianjin, China
The Affiliated Cancer Hospital of Xinjiang Medical University /ID# 240094, Urumqi, Xinjiang, China
Yunnan Cancer Hospital /ID# 251388, Kunming, Yunnan, China
The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 232032, Hangzhou, Zhejiang, China
Zhejiang Cancer hospital /ID# 242476, Hangzhou, Zhejiang, China
Taizhou Hospital of Zhejiang Province /ID# 232021, Linhai, Zhejiang, China
Ningbo No. 2 Hospital /ID# 242478, Ningbo, , China
Tianjin Medical University General Hospital /ID# 231839, Tianjin, , China
Masarykuv onkologicky ustav /ID# 232426, Brno, , Czechia
Nemocnice AGEL Novy Jicin, a.s. /ID# 232427, Novy Jicin, , Czechia
Roskilde Sygehus /ID# 241842, Roskilde, Sjælland, Denmark
Odense University Hospital /ID# 241663, Odense, Syddanmark, Denmark
APHM - Hopital Nord /ID# 251935, Marseille, Bouches-du-Rhone, France
Centre Hospitalier Universitaire de Bordeaux /ID# 244953, Pessac CEDEX, Gironde, France
CHU Lille - Hôpital Albert Calmette /ID# 251934, Lille, Hauts-de-France, France
Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 239409, Paris CEDEX 14, Paris, France
Hospices Civils de Lyon (HCL) - Hopital Louis Pradel /ID# 251933, Bron, Rhone, France
Centre Hosp Intercommunal de Creteil /ID# 251936, Creteil, Val-de-Marne, France
Hopital Arnaud de Villeneuve /ID# 239404, Montpellier Cedex 5, , France
AP-HP - Hopital Tenon /ID# 239179, Paris, , France
Universitatsklinikum Mannheim /ID# 238331, Mannheim, Baden-Wuerttemberg, Germany
Universitaetsklinikum Giessen /ID# 252973, Gießen, Hessen, Germany
Klinikum Kassel /ID# 240142, Kassel, Hessen, Germany
Universitaetsklinikum Jena /ID# 239661, Jena, Thueringen, Germany
Charite Universitaetsklinikum Berlin - Campus Virchow /ID# 234247, Berlin, , Germany
Universitaetsklinikum Hamburg-Eppendorf /ID# 239658, Hamburg, , Germany
Haemato-Onkologie Hamburg /ID# 241047, Hamburg, , Germany
Thoraxklinik Heidelberg gGmbH /ID# 239656, Heidelberg, , Germany
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 230824, Athens, Attiki, Greece
Metropolitan Hospital /ID# 232158, Piraeus, Attiki, Greece
Metropolitan Hospital /ID# 239170, Piraeus, Attiki, Greece
Euromedica General Clinic /ID# 254407, Thessaloniki, , Greece
The Edith Wolfson Medical Center /ID# 233781, Ashkelon, HaDarom, Israel
Soroka University Medical Center /ID# 252711, Be'er Sheva, HaDarom, Israel
ZIV Medical Center /ID# 238606, Safed, HaTsafon, Israel
Tel Aviv Sourasky Medical Center /ID# 260519, Tel Aviv, Tel-Aviv, Israel
Azienda Ospedaliera San Giovanni Addolorata /ID# 238618, Rome, Roma, Italy
Azienda Ospedaliera di Perugia /ID# 238473, Perugia, Umbria, Italy
I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 238696, Bari, , Italy
Azienda Socio Sanitaria Territoriale di Cremona /ID# 238698, Cremona, , Italy
Azienda Ospedaliera Papardo /ID# 258038, Messina, , Italy
AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 252942, Napoli, , Italy
ASST Sette Laghi /ID# 238536, Varese, , Italy
NHO Nagoya Medical Center /ID# 246306, Nagoya-shi, Aichi, Japan
Nagoya University Hospital /ID# 239990, Nagoya-shi, Aichi, Japan
Hirosaki University Hospital /ID# 242377, Hirosaki-shi, Aomori, Japan
National Cancer Center Hospital East /ID# 233775, Kashiwa-shi, Chiba, Japan
National Hospital Organization Kyushu Medical Center /ID# 238533, Fukuoka shi, Fukuoka, Japan
Hospital of the University of Occupational and Environmental Health, Japan /ID# 241191, Kitakyushu-shi, Fukuoka, Japan
Kurume University Hospital /ID# 254900, Kurume-shi, Fukuoka, Japan
Fukushima Medical University Hospital /ID# 249691, Fukushima-shi, Fukushima, Japan
Gunma Prefectural Cancer Center /ID# 233723, Ota-shi, Gunma, Japan
Chugoku Central Hospital /ID# 242970, Fukuyama, Hiroshima, Japan
Hiroshima University Hospital /ID# 241882, Hiroshima-shi, Hiroshima, Japan
Hokkaido University Hospital /ID# 241289, Sapporo-shi, Hokkaido, Japan
Kobe Minimally Invasive Cancer Center /ID# 254131, Kobe-shi, Hyogo, Japan
Takarazuka City Hospital /ID# 240786, Takarazuka-shi, Hyogo, Japan
National Hospital Organization Mito Medical Center /ID# 241709, Higashi Ibaraki-gun, Ibaraki, Japan
Ibaraki Prefectural Central Hospital /ID# 246145, Kasama-shi, Ibaraki, Japan
Iwate Medical University Hospital /ID# 239027, Shiwa-gun, Iwate, Japan
Kitasato University Hospital /ID# 239958, Sagamihara-shi, Kanagawa, Japan
Yokohama City University Medical Center /ID# 246554, Yokohama shi, Kanagawa, Japan
Kanagawa Cardiovascular and Respiratory Center /ID# 239052, Yokohama-shi, Kanagawa, Japan
Kumamoto University Hospital /ID# 241039, Kumamoto shi, Kumamoto, Japan
National Hospital Organization Mie Chuo Medical Center /ID# 246659, Tsu-shi, Mie, Japan
Miyagi Cancer Center /ID# 234198, Natori-shi, Miyagi, Japan
Sendai Kousei Hospital /ID# 253350, Sendai-shi, Miyagi, Japan
University of Miyazaki Hospital /ID# 242161, Miyazaki-shi, Miyazaki, Japan
Nagaoka Red Cross Hospital /ID# 240714, Nagaoka-shi, Niigata, Japan
Kurashiki Central Hospital /ID# 239344, Kurashiki-shi, Okayama, Japan
Osaka Habikino Medical Center /ID# 239989, Habikino-shi, Osaka, Japan
Kansai Medical University Hospital /ID# 233476, Hirakata-shi, Osaka, Japan
Osaka Metropolitan University Hospital /ID# 238895, Osaka-shi, Osaka, Japan
Kindai University Hospital /ID# 239085, Osakasayama-shi, Osaka, Japan
Tochigi Cancer Center /ID# 240020, Utsunomiya-shi, Tochigi, Japan
Juntendo University Hospital /ID# 239932, Bunkyo-ku, Tokyo, Japan
National Cancer Center Hospital /ID# 251134, Chuo-ku, Tokyo, Japan
National Hospital Organization Tokyo Medical Center /ID# 246581, Meguro-ku, Tokyo, Japan
NTT Medical Center Tokyo /ID# 241067, Shinagawa-ku, Tokyo, Japan
Keio University Hospital /ID# 239506, Shinjuku-ku, Tokyo, Japan
Toyama University Hospital /ID# 241660, Toyama-shi, Toyama, Japan
Wakayama Medical University Hospital /ID# 234004, Wakayama-shi, Wakayama, Japan
Yamagata University Hospital /ID# 240815, Yamagata-shi, Yamagata, Japan
Yamaguchi - Ube Medical Center /ID# 258779, Ube-shi, Yamaguchi, Japan
Fujieda Municipal General Hospital /ID# 255155, Fujieda-shi, , Japan
Chungbuk National University Hospital /ID# 257891, Cheongju, Chungcheongbugdo, Korea, Republic of
National Cancer Center /ID# 260663, Goyang-si, Gyeonggido, Korea, Republic of
CHA Bundang Medical Center /ID# 233318, Seongnam, Gyeonggido, Korea, Republic of
Ajou University Hospital /ID# 233319, Suwon-si, Gyeonggido, Korea, Republic of
The Catholic University Of Korea St. Vincent's Hospital /ID# 256942, Suwon, Gyeonggido, Korea, Republic of
Gyeongsang National University Hospital /ID# 234244, Jinju, Gyeongsangnamdo, Korea, Republic of
Pusan National University Yangsan Hospital /ID# 257836, Yangsan-si, Gyeongsangnamdo, Korea, Republic of
Kangbuk Samsung Hospital /ID# 233711, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Samsung Medical Center /ID# 256941, Seoul, , Korea, Republic of
SMG-SNU Boramae Medical Center /ID# 233710, Seoul, , Korea, Republic of
O.P.D. Hospital Civil de Guadalajara /ID# 238488, Guadalajara, Jalisco, Mexico
Centro de Investigacion Clínica Chapultepec SA de CV /ID# 231928, Morelia, Michoacan, Mexico
Clinical Research & Oncology Oaxaca /ID# 231883, Oaxaca, , Mexico
HagaZiekenhuis /ID# 243693, Den Haag, , Netherlands
Ziekenhuis St. Jansdal /ID# 251932, Harderwijk, , Netherlands
Maastricht Universitair Medisch Centrum /ID# 233932, Maastricht, , Netherlands
Isala /ID# 238846, Zwolle, , Netherlands
Instytut Centrum Zdrowia Matki Polki /ID# 239024, Lodz, Lodzkie, Poland
MRUK-MED I Sp. z o.o. /ID# 239363, Rzeszow, Podkarpackie, Poland
Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie /ID# 239025, Olsztyn, Warminsko-mazurskie, Poland
Fundacao Champalimaud /ID# 241925, Lisbon, Lisboa, Portugal
Centro Hospitalar Universitario do Porto, EPE - Hospital Santo Antonio /ID# 241572, Porto, , Portugal
Hospital CUF Porto /ID# 241570, Porto, , Portugal
IPO Porto FG, EPE /ID# 241569, Porto, , Portugal
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 241930, Porto, , Portugal
Spitalul Pelican /ID# 254066, Oradea, Bihor, Romania
Cardiomed Srl /Id# 255320, Cluj-Napoca, Cluj, Romania
Institutul Regional de Oncologie /ID# 254065, Jassi, Iasi, Romania
SC RTC Radiology Therapeutic Center SRL /ID# 240744, Otopeni, Ilfov, Romania
Oncocenter - Oncologie Clinica Srl /Id# 239103, Timisoara, Timis, Romania
Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL /ID# 240826, Brasov, , Romania
Sc Oncolab Srl /Id# 239105, Craiova, , Romania
S.C. Sigmedical Services SRL /ID# 239108, Suceava, , Romania
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 230084, Banska Bystrica, , Slovakia
Wits Clinical Research /ID# 230841, Johannesburg, Gauteng, South Africa
Sandton Oncology Medical Group PTY Ltd /ID# 230843, Johannesburg, Gauteng, South Africa
Dept Medical Oncology, University of Pretoria and Steve Biko Academic Hospital /ID# 230883, Pretoria, Gauteng, South Africa
CHU Insular-Materno Infantil /ID# 255094, Las Palmas de Gran Canaria, Las Palmas, Spain
Hospital Universitario Fundacion Alcorcon /ID# 255100, Alcorcon, Madrid, Spain
Hospital Universitario de Fuenlabrada /ID# 255093, Fuenlabrada, Madrid, Spain
Hospital Nuestra Senora de Sonsoles /ID# 255102, Avila, , Spain
UOMi Cancer Center - Clinica Tres Torres /ID# 240584, Barcelona, , Spain
Hospital Universitario Dexeus - Grupo Quironsalud /ID# 255105, Barcelona, , Spain
Hospital Universitario de Jaen /ID# 240588, Jaen, , Spain
Hospital Universitario 12 de Octubre /ID# 240176, Madrid, , Spain
Hospital Clinico Universitario de Valencia /ID# 240378, Valencia, , Spain
Karolinska University Hospital Solna /ID# 229853, Solna, Stockholms Lan, Sweden
Sahlgrenska Universitetssjukhuset /ID# 229943, Göteborg, Vastra Gotalands Lan, Sweden
National Taiwan University Hospital /ID# 238378, Taipei City, Taipei, Taiwan
Mackay Memorial Hospital /ID# 238392, Taipei City, Taipei, Taiwan
Changhua Christian Hospital /ID# 238394, Changhua City, Changhua County, , Taiwan
National Taiwan University Hospital - Hsinchu branch /ID# 238393, Hsinchu City, , Taiwan
Hualien Tzu Chi Hospital /ID# 238398, Hualien City, , Taiwan
E-DA Cancer Hospital /ID# 239718, Kaohsiung City, , Taiwan
Chung Shan Medical University Hospital /ID# 238444, Taichung, , Taiwan
Taipei Medical University Hospital /ID# 238380, Taipei City, , Taiwan
Memorial Ankara Hastanesi /ID# 234212, Çankaya, Ankara, Turkey
Izmir Ekonomi Universitesi Ozel Medicalpoint Hastanesi /ID# 234209, Karsiyaka, Izmir, Turkey
Adana Acıbadem Hospital /ID# 234208, Adana, , Turkey
Medical Park Seyhan Hastanesi /ID# 255637, Adana, , Turkey
Ankara City Hospital /ID# 234210, Ankara, , Turkey
Inonu Universitesi Turgut Ozal /ID# 234038, Battalgazi/malatya, , Turkey
Uludag University Medical Faculty /ID# 234205, Bursa, , Turkey
Dicle Universitesi Tip /ID# 234036, Diyarbakir, , Turkey
Bagcilar Medipol Mega Universite Hastanesi /ID# 234211, Istanbul, , Turkey
Ege University Medical Faculty /ID# 234039, Izmir, , Turkey
Barts Health NHS Trust /ID# 254342, London, London, City Of, United Kingdom
Nottingham City Hospital /ID# 254707, Nottingham, Nottinghamshire, United Kingdom
University College London Hospitals NHS Foundation Trust /ID# 249407, London, , United Kingdom
The Royal Marsden NHS Foundation Trust /ID# 246974, London, , United Kingdom
The Christie Hospital /ID# 243422, Manchester, , United Kingdom
Name: ABBVIE INC.
Affiliation: AbbVie
Role: STUDY_DIRECTOR