Spots Global Cancer Trial Database for A Study of Avastin (Bevacizumab) in Combination With Platinum-Based Chemotherapy in Patients With Advanced or Recurrent Squamous Non-Small Cell Lung Cancer
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Trial Identification
Brief Title: A Study of Avastin (Bevacizumab) in Combination With Platinum-Based Chemotherapy in Patients With Advanced or Recurrent Squamous Non-Small Cell Lung Cancer
Official Title: An Open Label Study of the Safety of First-line Treatment With Avastin in Combination With Cisplatin-gemcitabine or Carboplatin-paclitaxel in Patients With Advanced or Recurrent Squamous Non-small Cell Lung Cancer, Who Are Considered to be at High Risk of Pulmonary Haemorrhage
Study ID: NCT00404703
Conditions
Study Description
Brief Summary: This single arm study will assess the feasibility of using Avastin plus platinum-based chemotherapy (cisplatin-gemcitabine or carboplatin-paclitaxel) in patients with advanced or recurrent squamous non-small cell lung cancer who have not received prior chemotherapy. Patients will receive preventive radiation, followed by one cycle of chemotherapy alone and 5 cycles of chemotherapy in combination with Avastin (15mg/kg iv on day 1 of each 3 weekly cycle), followed by Avastin alone for a maximum total treatment period with Avastin of 12 months. The anticipated time on study treatment is 3-12 months, and the target sample size is \<100 individuals.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
, Tugun, , Australia
, Wollongong, , Australia
, Liege, , Belgium
, Ostrava, , Czech Republic
, Usti nad Labem, , Czech Republic
, Bobigny, , France
, Marseille, , France
, Nantes, , France
, Szekesfehervar, , Hungary
, Szombathely, , Hungary
, Kfar Saba, , Israel
, Ramat Gan, , Israel
, Lublin, , Poland
, Poznan, , Poland
, Szczecin, , Poland
, Warszawa, , Poland
, Balashikha, , Russian Federation
, Moscow, , Russian Federation
, St. Petersburg, , Russian Federation
, Madrid, , Spain
, Sevilla, , Spain
, Kueishan, , Taiwan
, Taichung, , Taiwan
, Taipei, , Taiwan
, Taoyuan, , Taiwan
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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