Spots Global Cancer Trial Database for A Study of Avastin (Bevacizumab) in Patients With Non-Squamous Non-Small Cell Lung Cancer With Asymptomatic Untreated Brain Metastasis
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Trial Identification
Brief Title: A Study of Avastin (Bevacizumab) in Patients With Non-Squamous Non-Small Cell Lung Cancer With Asymptomatic Untreated Brain Metastasis
Official Title: An Open Label Study to Assess the Effect of Avastin (Bevacizumab) Combined With First Line Paclitaxel-carboplatin or Second Line Tarceva (Erlotinib) on Progression-free Survival in Non-squamous Non-small Cell Lung Cancer Patients With Asymptomatic Untreated Brain Metastasis
Study ID: NCT00800202
Conditions
Study Description
Brief Summary: This study will assess the efficacy and safety of Avastin combined with first li ne paclitaxel-carboplatin (cohort 1) or second line Tarceva (cohort 2) in patien ts with non-squamous non-small cell lung cancer with asymptomatic untreated brai n metastasis. Two cohorts of patients will be studied; the first will receive Av astin 15mg/kg iv every 3 weeks combined with first line paclitaxel 200mg/m2 iv p lus carboplatin AUC6 iv every 3 weeks for a maximum of 6 cycles, and the second cohort will receive Avastin 15mg/kg iv every 3 weeks combined with second line T arceva 150mg/kg po.The anticipated time on study treatment is until disease prog ression, and the target sample size is 100-500 individuals.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
, Bordeaux, , France
, Brest, , France
, Caen, , France
, Chartres, , France
, Creteil, , France
, GAP, , France
, Gleize, , France
, La Tronche, , France
, Lille, , France
, Lyon, , France
, Marseille, , France
, Marseille, , France
, Montpellier, , France
, Paris, , France
, Paris, , France
, Paris, , France
, Paris, , France
, Pierre Benite, , France
, Rennes, , France
, Saint Herblain, , France
, Strasbourg, , France
, Toulon, , France
, Toulouse, , France
, Vandoeuvre Les Nancy, , France
, Vandoeuvre-les-nancy, , France
, Villejuif, , France
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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