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Brief Title: A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC)
Official Title: A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Patients Selected According to Biomarker Status, With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer
Study ID: NCT05170204
Brief Summary: This study will evaluate the efficacy and safety of multiple therapies in participants with locally advanced, unresectable, Stage III NSCLC with eligible biomarker status as determined by Version 8 of the American Joint Committee on Cancer/Union for International Cancer Control NSCLC staging system.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Southern California Kaiser Permanente, San Diego, California, United States
Rocky Mountain Cancer Centers - Lone Tree, Lone Tree, Colorado, United States
Mount Sinai Medical Center; Comprehensive Cancer Center, Miami Beach, Florida, United States
University Of Michigan, Ann Arbor, Michigan, United States
Oregon Health Sciences Uni, Portland, Oregon, United States
Northwest Cancer Specialists, P.C., Tigard, Oregon, United States
Hillman Cancer Center;Medical Oncology, Pittsburgh, Pennsylvania, United States
Thompson Cancer Survival Center, Knoxville, Tennessee, United States
Baptist Cancer Center, Memphis, Tennessee, United States
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Mays Cancer Center, UT Health San Antonio, San Antonio, Texas, United States
Virginia Cancer Specialists (Fairfax) - USOR, Fairfax, Virginia, United States
Lifehouse, Camperdown, New South Wales, Australia
Northern Cancer Institute, St Leonards, New South Wales, Australia
Westmead Hospital; Medical Oncology and Pallative Care, Westmead, New South Wales, Australia
Peter MacCallum Cancer Centre; Medical Oncology, Melbourne, Victoria, Australia
One Clinical Research, Nedlands, Western Australia, Australia
GHdC Site Notre Dame, Charleroi, , Belgium
UZ Gent, Gent, , Belgium
Hospital Sao Rafael - HSR, Salvador, BA, Brazil
Crio - Centro Regional Integrado de Oncologia, Fortaleza, CE, Brazil
Oncocentro Belo Horizonte, Belo Horizonte, MG, Brazil
COT - Centro Oncologico do Triangulo, Uberlandia, MG, Brazil
Oncoclinicas Rio de Janeiro S.A., Rio de Janeiro, RJ, Brazil
Santa Casa de Misericordia de Porto Alegre, Porto Alegre, RS, Brazil
Hospital Nossa Senhora da Conceicao, Porto Alegre, RS, Brazil
Clínica de Oncologia Reichow, Blumenau, SC, Brazil
Hospital de Cancer de Barretos, Barretos, SP, Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, SP, Brazil
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Centro de Estudios Clínicos SAGA, Santiago, , Chile
OrlandiOncología, Santiago, , Chile
James Lind Centro de Investigación Del Cáncer, Temuco, , Chile
Beijing Cancer Hospital, Beijing, , China
Hunan Cancer Hospital, Changsha CITY, , China
Hunan Cancer Hospital, Changsha CITY, , China
Xinqiao Hospital of Third Military Medical University, Chongqing City, , China
Shandong Cancer Hospital, Jinan, , China
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing City, , China
The affiliated hospital of Qingdao university, Qingdao City, , China
Shanghai Pulmonary Hospital, Shanghai, , China
Tianjin Medical University Cancer Institute & Hospital, Tianjin, , China
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan City, , China
Shanxi Cancer Hospital, Xi'an, , China
Clinica De La Costa, Barranquilla, , Colombia
Fundación CTIC - Centro de Tratamiento e Investigación sobre Cáncer Luis Carlos Sarmiento Angulo, Bogota, D.C., , Colombia
Hospital Universitario San Ignacio, Bogota, , Colombia
Fundacion Cardioinfantil, Bogota, , Colombia
Instituto Cancerologia Medellin; Clinica Las Americas, Medellin, , Colombia
Clinica CIMCA, San José, , Costa Rica
ICIMED Instituto de Investigación en Ciencias Médicas, San José, , Costa Rica
CHU Angers,Service de Pneumologie, Angers, , France
Centre Leon Berard, Lyon, , France
Hopital Nord; Pneumologie, Marseille cedex 20, , France
Hôpitaux D'Instruction Des Armees Begin, St Mande, , France
Hia Sainte Anne; Pneumologie, Toulon, , France
CHU de Toulouse - Hôpital Larrey, Toulouse, , France
Helios Klinikum Emil von Behring GmbH, Berlin, , Germany
Klinikum Chemnitz gGmbH, Chemnitz, , Germany
Klinikum Esslingen; Klinik für Kardiologie, Angiologie und Pneumologie, Esslingen, , Germany
Thoraxklinik Heidelberg gGmbH, Heidelberg, , Germany
LMU Klinikum der Universität München, Medizinische Klinik und Poliklinik V, Campus Innenstadt, München, , Germany
Universitätsklinikum Regensburg; Klinik und Poliklinik für Innere Medizin II, Pneumologie, Regensburg, , Germany
Queen Mary Hospital; Dept. of Clinical Oncology, Hong Kong, , Hong Kong
Rambam Medical Center; Oncology, Haifa, , Israel
Rabin Medical Center-Beilinson Campus; Davidof Institute, Petach Tikva, , Israel
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola, Emilia-Romagna, Italy
Azienda Ospedaliera San Camillo Forlanini; U.O.C. Pneumologia Ad Indirizzo Oncologico 1, Roma, Lazio, Italy
IRCCS A.O.U San MArtino - IST; U.O. Oncologia Medica 2, Genova, Liguria, Italy
ASST DEGLI SPEDALI CIVILI DI BRESCIA; Oncologia Medica, Brescia, Lombardia, Italy
Irccs Istituto Europeo di Oncologia (IEO); Divisione di Oncologia, Milano, Lombardia, Italy
Asst Grande Ospedale Metropolitano Niguarda; Dipartimento Di Ematologia Ed Oncologia, Milano, Lombardia, Italy
A.O. UNIVERSITARIA S. LUIGI GONZAGA; Oncologia Medica, Orbassano, Piemonte, Italy
Azienda Ospedaliero-Universitaria Careggi; SOD Radioterapia, Firenze, Toscana, Italy
IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda, Padova, Veneto, Italy
Ospedale P. Pederzoli Casa di cura Privata; Lung Unit Thoracic 3° Floor, Peschiera Del Garda (VR), Veneto, Italy
Aichi Cancer Center Hospital, Aichi, , Japan
Hirosaki University Hospital, Aomori, , Japan
National Cancer Center East, Chiba, , Japan
Shikoku Cancer Center, Ehime, , Japan
NHO Kyushu Cancer Center, Fukuoka, , Japan
Kurume University Hospital, Fukuoka, , Japan
Kobe City Medical Center General Hospital, Hyogo, , Japan
National Hospital Organization Himeji Medical Center, Hyogo, , Japan
Kagoshima University Hospital, Kagoshima, , Japan
Kanagawa Cancer Center, Kanagawa, , Japan
Kumamoto University Hospital, Kumamoto, , Japan
Sendai Kousei Hospital, Miyagi, , Japan
Nara Medical University Hospital, Nara, , Japan
Niigata Cancer Center Hospital, Niigata, , Japan
Okayama University Hospital, Okayama, , Japan
Kurashiki Central Hospital, Okayama, , Japan
Kindai University Hospital ; Faculty of Medicine, Osaka-sayama, , Japan
Osaka City General Hospital, Osaka, , Japan
Osaka International Cancer Institute, Osaka, , Japan
NHO Kinki Chuo Chest Medical Center, Osaka, , Japan
Shizuoka Cancer Center, Shizuoka, , Japan
Juntendo University Hospital, Tokyo, , Japan
Komagome Hospital, Tokyo, , Japan
The Cancer Institute Hospital of JFCR, Tokyo, , Japan
Tottori University Hospital, Tottori, , Japan
National Hospital Organization Yamaguchi - Ube Medical Center, Yamaguchi, , Japan
Chungbuk National University Hospital, Cheongju si, , Korea, Republic of
Kyungpook National University Chilgok Hospital, Daegu, , Korea, Republic of
Pusan National University Yangsan Hospital, Gyeongsangnam-do, , Korea, Republic of
Chonnam National University Hwasun Hospital, Jeollanam-do, , Korea, Republic of
Seoul National University Bundang Hospital, Seongnam-si, , Korea, Republic of
Kangbuk Samsung Hospital, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Korea University Guro Hospital, Seoul, , Korea, Republic of
Auckland City Hospital, Cancer and Blood Research, Auckland, , New Zealand
Oslo universitetssykehus HF, Ullevål, Kreftsenteret, Oslo, , Norway
Instytut Genetyki i Immunologii GENIM, Lublin, , Poland
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie; Oddzial onkologii z pododdzialem chemioterapii, Olsztyn, , Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu, Poznan, , Poland
Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad; Klinika Nowot.Pluca i Klatki Piers, Warszawa, , Poland
Dolno?l?skie Centrum Chorób P?uc we Wroc?awiu; Oddzia? Onkologii Klinicznej VII, Wroc?aw, , Poland
University Clinical Centre of Serbia; Clinic for Pulmonology, Belgrade, , Serbia
Hospital Medical Center Bezanijska kosa; Clinic for Medical Oncology, Belgrade, , Serbia
Univ Clinical Center Kragujevac; Clinic for Pulmonology, Kragujevac, , Serbia
Institute for Pulmonary Diseases of Vojvodina; Clinic for Pulmonary Oncology, Sremska Kamenica, , Serbia
National Cancer Centre; Medical Oncology, Singapore, , Singapore
Tan Tock Seng Hospital; Oncology, Singapore, , Singapore
Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Oncologia, A Coruña, LA Coruña, Spain
Complejo Hospitalario Universitario Insular?Materno Infantil; Servicio de Oncologia, Las Palmas de Gran Canaria, LAS Palmas, Spain
Hospital General Univ. de Alicante; Servicio de Oncologia, Alicante, , Spain
Hospital Universitari Vall d'Hebron; Oncology, Barcelona, , Spain
Hospital Ramon y Cajal; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid, , Spain
Hospital Universitario La Paz; Servicio de Oncologia, Madrid, , Spain
Hospital Regional Universitario Carlos Haya; Servicio de Oncologia, Malaga, , Spain
Hospital Universitario Virgen del Rocio; Servicio de Oncologia, Sevilla, , Spain
Hospital Clínico Universitario de Valencia; Servicio de Oncología, Valencia, , Spain
Sahlgrenska University Hospital; Sahlgrenska Clinical Trial unit / Department of Oncology, Göteborg, , Sweden
Karolinska Universitetssjukhuset, Solna; Kliniska prövningsenheten Z:4:01, Stockholm, , Sweden
Taipei Medical University ?Shuang Ho Hospital, New Taipei City, , Taiwan
National Cheng Kung Univ Hosp, Tainan, , Taiwan
National Taiwan Uni Hospital, Taipei City, , Taiwan
Taipei Veterans General Hospital, Taipei City, , Taiwan
Taipei Medical University Hospital, Taipei, , Taiwan
Taipei Municipal Wan Fang Hospital, Taipei, , Taiwan
Chang Gung Memorial Hospital - Linkou, Taoyuan, , Taiwan
Taichung Veterans General Hospital, Xitun Dist., , Taiwan
Rajavithi Hospital; Division of Medical Oncology, Bangkok, , Thailand
Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology, Bangkok, , Thailand
Oncology Unit, Faculty of Medicine, Vajira Hospital; Department of Medicine, Dusit, , Thailand
Songklanagarind Hospital; Department of Internal Medicine, Division of Respiratory, Songkhla, , Thailand
Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology, Adana, , Turkey
Gazi Uni Medical Faculty Hospital; Oncology Dept, Ankara, , Turkey
Liv Hospital Ankara; Medical Oncology, Ankara, , Turkey
Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji, Bakirkoy / Istanbul, , Turkey
Ataturk University Medical Faculty Yakutiye Research Hospital Medical Oncology Department, Erzurum, , Turkey
Medipol University Medical Faculty; Oncology Department, Istanbul, , Turkey
Istanbul Uni Cerrahpasa Medical Faculty Hospital; Medical Oncology, Istanbul, , Turkey
Marmara Uni Faculty of Medicine; Medical Oncology, Istanbul, , Turkey
Medikal Park Samsun, Samsun, , Turkey
Birmingham Heartlands Hospital, Birmingham, , United Kingdom
Velindre Cancer Centre; Oncology Dept, Cardiff, , United Kingdom
Barts & London School of Med; Medical Oncology, London, , United Kingdom
Royal Marsden Hospital; Dept of Med-Onc, London, , United Kingdom
Christie Hospital Nhs Trust; Medical Oncology, Manchester, , United Kingdom
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR