Spots Global Cancer Trial Database for LDK378 Versus Chemotherapy in ALK Rearranged (ALK Positive) Patients Previously Treated With Chemotherapy (Platinum Doublet) and Crizotinib
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Trial Identification
Brief Title: LDK378 Versus Chemotherapy in ALK Rearranged (ALK Positive) Patients Previously Treated With Chemotherapy (Platinum Doublet) and Crizotinib
Official Title: A Phase III, Multicenter, Randomized, Open-label Study of Oral LDK378 Versus Standard Chemotherapy in Adult Patients With ALK-rearranged (ALK-positive) Advanced Non-small Cell Lung Cancer Who Have Been Treated Previously With Chemotherapy (Platinum Doublet) and Crizotinib
Study ID: NCT01828112
Conditions
Study Description
Brief Summary: The primary purpose of the study was to compare the antitumor activity of LDK378 vs. chemotherapy in patients previously treated with chemotherapy (platinum doublet) and crizotinib. Patients in the chemotherapy arm were given the option to switch to LDK378 after confirmed progressive disease (PD), while also had the choice to continue with pemetrexed treatment.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Novartis Investigative Site, Fayetteville, Arkansas, United States
Novartis Investigative Site, Hollywood, Florida, United States
Novartis Investigative Site, Jacksonville, Florida, United States
Novartis Investigative Site, Miami, Florida, United States
Novartis Investigative Site, Maywood, Illinois, United States
Novartis Investigative Site, Iowa City, Iowa, United States
Novartis Investigative Site, Boston, Massachusetts, United States
Novartis Investigative Site, Tulsa, Oklahoma, United States
Novartis Investigative Site, Nashville, Tennessee, United States
Novartis Investigative Site, Sugar Land, Texas, United States
Novartis Investigative Site, Waco, Texas, United States
Novartis Investigative Site, Fairfax, Virginia, United States
Novartis Investigative Site, Seattle, Washington, United States
Novartis Investigative Site, Edegem, Antwerpen, Belgium
Novartis Investigative Site, Bruxelles, , Belgium
Novartis Investigative Site, Bruxelles, , Belgium
Novartis Investigative Site, Leuven, , Belgium
Novartis Investigative Site, Toronto, Ontario, Canada
Novartis Investigative Site, Marseille cedex 20, Bouches Du Rhone, France
Novartis Investigative Site, Le Mans, Cedex 09, France
Novartis Investigative Site, Besancon cedex, , France
Novartis Investigative Site, Brest, , France
Novartis Investigative Site, Caen, , France
Novartis Investigative Site, Mulhouse cedex, , France
Novartis Investigative Site, Paris, , France
Novartis Investigative Site, Strasbourg, , France
Novartis Investigative Site, Suresnes, , France
Novartis Investigative Site, Bad Berka, , Germany
Novartis Investigative Site, Essen, , Germany
Novartis Investigative Site, Esslingen, , Germany
Novartis Investigative Site, Frankfurt, , Germany
Novartis Investigative Site, Heidelberg, , Germany
Novartis Investigative Site, Koeln, , Germany
Novartis Investigative Site, Tuebingen, , Germany
Novartis Investigative Site, Ulm, , Germany
Novartis Investigative Site, Hong Kong, , Hong Kong
Novartis Investigative Site, Limerick, Co Limerick, Ireland
Novartis Investigative Site, Dublin 4, , Ireland
Novartis Investigative Site, Kfar Saba, , Israel
Novartis Investigative Site, Ramat Gan, , Israel
Novartis Investigative Site, Avellino, AV, Italy
Novartis Investigative Site, Monza, MB, Italy
Novartis Investigative Site, Milano, MI, Italy
Novartis Investigative Site, Perugia, PG, Italy
Novartis Investigative Site, Pisa, PI, Italy
Novartis Investigative Site, Aviano, PN, Italy
Novartis Investigative Site, Reggio Emilia, RE, Italy
Novartis Investigative Site, Roma, RM, Italy
Novartis Investigative Site, Orbassano, TO, Italy
Novartis Investigative Site, Verona, VR, Italy
Novartis Investigative Site, Nagoya, Aichi, Japan
Novartis Investigative Site, Kashiwa, Chiba, Japan
Novartis Investigative Site, Fukuoka city, Fukuoka, Japan
Novartis Investigative Site, Fukuoka-city, Fukuoka, Japan
Novartis Investigative Site, Akashi, Hyogo, Japan
Novartis Investigative Site, Okayama-city, Okayama, Japan
Novartis Investigative Site, Hirakata-city, Osaka, Japan
Novartis Investigative Site, Osaka Sayama, Osaka, Japan
Novartis Investigative Site, Osaka-city, Osaka, Japan
Novartis Investigative Site, Takatsuki-city, Osaka, Japan
Novartis Investigative Site, Koto ku, Tokyo, Japan
Novartis Investigative Site, Niigata, , Japan
Novartis Investigative Site, Seoul, Korea, Korea, Republic of
Novartis Investigative Site, Seoul, Seocho Gu, Korea, Republic of
Novartis Investigative Site, Seoul, , Korea, Republic of
Novartis Investigative Site, Seoul, , Korea, Republic of
Novartis Investigative Site, Seoul, , Korea, Republic of
Novartis Investigative Site, Ashrafieh, , Lebanon
Novartis Investigative Site, Amsterdam, , Netherlands
Novartis Investigative Site, Groningen, , Netherlands
Novartis Investigative Site, Lisboa, , Portugal
Novartis Investigative Site, Moscow Region Istra Village, , Russian Federation
Novartis Investigative Site, Moscow, , Russian Federation
Novartis Investigative Site, Saint Petersburg, , Russian Federation
Novartis Investigative Site, Singapore, , Singapore
Novartis Investigative Site, Singapore, , Singapore
Novartis Investigative Site, Madrid, Andalucia, Spain
Novartis Investigative Site, Sevilla, Andalucia, Spain
Novartis Investigative Site, Barcelona, Catalunya, Spain
Novartis Investigative Site, Barcelona, Cataluña, Spain
Novartis Investigative Site, Valencia, Comunidad Valenciana, Spain
Novartis Investigative Site, La Coruna, Galicia, Spain
Novartis Investigative Site, Santiago de Compostela, Galicia, Spain
Novartis Investigative Site, Madrid, , Spain
Novartis Investigative Site, Madrid, , Spain
Novartis Investigative Site, Madrid, , Spain
Novartis Investigative Site, Madrid, , Spain
Novartis Investigative Site, Luzern, , Switzerland
Novartis Investigative Site, St. Gallen, , Switzerland
Novartis Investigative Site, Istanbul, TUR, Turkey
Novartis Investigative Site, Ankara, , Turkey
Novartis Investigative Site, Pendik Istanbul, , Turkey
Novartis Investigative Site, Cheltenham, Gloucestershire, United Kingdom
Novartis Investigative Site, Hants, Southampton, United Kingdom
Novartis Investigative Site, Aberdeen, , United Kingdom
Novartis Investigative Site, Leicester, , United Kingdom
Novartis Investigative Site, London, , United Kingdom
Contact Details
Name: Novartis Pharmaceuticals
Affiliation: Novartis Pharmaceuticals
Role: STUDY_DIRECTOR
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