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Brief Title: Cohort of Patients With NSCLC Treated With Nivolumab Under the ATU Program
Official Title: Assessment and Follow-up of Patients With Non-small Cell Lung Cancer (NSCLC) Treated With Nivolumab Under the French Temporary Authorization for Use (ATU) Program
Study ID: NCT02933346
Brief Summary: Our study sought to examine nivolumab efficacy and safety in advanced NSCLC patients treated under the Temporary Authorization for Use (ATU, compassionate use) setting and describe their long-term clinical characteristics, notably the treatments they received after nivolumab discontinuation. The profile of these patients shows greater conformity to that of a non-selected population, yet the clinical data collection does not reflect "real life" conditions and stops when treatment ends, which does not enable us to get an overview of post-immunotherapy treatments.
Detailed Description: Although the oncogene addiction concept has led to effective targeted treatments for certain histological non-small cell lung cancer (NSCLC) types, most patients with advanced tumors are still treated with first-line chemotherapy. In 2015, several studiess demonstrated the efficacy of nivolumab, an immunotherapy targeting immune checkpoints. In France, besides the clinical trials, this molecule has been made available in January 2015 under a Temporary Authorization for Use (ATU, compassionate use). Our study sought to examine nivolumab efficacy and safety in advanced NSCLC patients treated under the ATU setting and describe their long-term clinical characteristics, notably the treatments they received after nivolumab discontinuation. The profile of these patients shows greater conformity to that of a non-selected population, yet the clinical data collection does not reflect "real life" conditions and stops when treatment ends, which does not enable us to get an overview of post-immunotherapy treatments.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
CH du Pays d'Aix, Aix-En-Provence, , France
Clinique du Rambot, Aix-En-Provence, , France
CHU d'Amiens-Picardie, Amiens, , France
CHU d'Angers, Angers, , France
CH Argenteuil, Argenteuil, , France
CH d'Avignon, Avignon, , France
Institut Sainte Catherine, Avignon, , France
CH de la Côte Basque, Bayonne, , France
CHU de Besançon, Besançon, , France
CH de Blois, Blois, , France
Hôpital Avicenne APHP, Bobigny, , France
CH Briançon, Briançon, , France
Hôpital Pradel HCL, Bron, , France
Caen CLCC, Caen, , France
CHU de Caen, Caen, , France
CH de Pontoise, Cergy Pontoise, , France
CH Métropole Savoie, Chambéry, , France
HIA Percy, Clamart, , France
Centre Jean Perrin, Clermont-Ferrand, , France
CHU de Clermont-Ferrand, Clermont-Ferrand, , France
CH Alpes Léman, Contamine Sur Arve, , France
Clinique des Cèdres, Cornebarrieu, , France
CHI de Créteil, Créteil, , France
CH de Dax, Dax, , France
Centre Georges-François Leclerc, Dijon, , France
Institut Daniel Hollard, Grenoble, , France
CHR Saint-Omer, Helfaut, , France
CHU Grenoble Alpes, La Tronche, , France
CHD Vendée, La-Roche-Sur-Yon, , France
CH de Versailles, Le Chesnay, , France
Hôpital Bicêtre APHP, Le Kremlin Bicêtre, , France
CH Le Mans, Le Mans, , France
CHRU de Lille, Lille, , France
CHU de Limoges, Limoges, , France
Polyclinique de Limoges, Limoges, , France
Centre Léon Bérard, Lyon, , France
HP Clairval, Marseille, , France
Hôpital Nord APHM, Marseille, , France
HP Robert Schumann, Metz, , France
CH de Mont-De-Masan, Mont-De-Marsan, , France
CH de Belfort Montbéliard, Montbéliard, , France
GRH Mulhouse Sud-Alsace, Mulhouse, , France
Centre d'Oncologie de Gentilly, Nancy, , France
Nice CLCC, Nice, , France
CHU Nîmes, Nîmes, , France
CHR d'Orléans, Orléans, , France
Hegp Aphp, Paris, , France
HIA Val de Grâce, Paris, , France
Hôpital Saint Joseph, Paris, , France
Hôpital Saint Louis APHP, Paris, , France
Hôpital Tenon APHP, Paris, , France
CH de Pau, Pau, , France
CHU de Bordeaux, Pessac, , France
CH Lyon-Sud HCL, Pierre-Bénite, , France
CH de Saint-Brieuc, Saint-Brieuc, , France
CHU de Nantes, Saint-Herblain, , France
ICO René Gauducheau, Saint-Herblain, , France
CH Annecy Genevois, Saint-Julien-en-Genevois, , France
HIA Begin, Saint-Mandé, , France
ICL Lucien Neuwirth, Saint-Priest-en-Jarez, , France
NHC CHRU de Strasbourg, Strasbourg, , France
Hôpital Foch, Suresnes, , France
CHI Toulon La Seyne Sur Mer, Toulon, , France
HIA Saint Anne, Toulon, , France
CHU Toulouse, Toulouse, , France
CHRU de Tours, Tours, , France
Clinique Saint Joseph, Trélazé, , France
CH de Valence, Valence, , France
CHU Bretagne Atlantique, Vannes, , France
Hôpital Nord-Ouest, Villefranche-Sur-Saône, , France
Gustave Roussy, Villejuif, , France
Hôpital Paul Brousse APHP, Villejuif, , France
Name: Olivier MOLINIER, MD
Affiliation: CH Le Mans, France
Role: PRINCIPAL_INVESTIGATOR