Spots Global Cancer Trial Database for A Study of Avastin (Bevacizumab) in Combination With Carboplatin-Based Chemotherapy in Patients With Advanced or Recurrent Non-Squamous Non-Small Cell Lung Cancer.
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Trial Identification
Brief Title: A Study of Avastin (Bevacizumab) in Combination With Carboplatin-Based Chemotherapy in Patients With Advanced or Recurrent Non-Squamous Non-Small Cell Lung Cancer.
Official Title: A Randomized, Open-label Study to Explore the Correlation of Biomarkers With Response Rate in Chemo-naive Patients With Advanced or Recurrent Non-squamous Non-small Cell Lung Cancer Who Receive Treatment With Avastin in Addition to Carboplatin-based Chemotherapy
Study ID: NCT00700180
Conditions
Study Description
Brief Summary: This study will explore the correlation of biomarkers with response rate, and the overall efficacy and safety, of Avastin in combination with carboplatin-based chemotherapy in patients with advanced or recurrent non-squamous non-small cell lung cancer. Patients will be randomized to one of 2 groups, to receive either Avastin 7.5mg/kg iv on day 1 of each 3 week cycle, or Avastin 15mg/kg iv on day 1 of each 3 week cycle; all patients will also receive treatment with carboplatin and either gemcitabine or paclitaxel for a maximum of 6 cycles. The anticipated time on study treatment is until disease progression, and the target sample size is 100-500 individuals.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
, St. Leonards, New South Wales, Australia
, Adelaide, South Australia, Australia
, Adelaide, South Australia, Australia
, Box Hill, Victoria, Australia
, Fitzroy, Victoria, Australia
, Antwerpen, , Belgium
, Liege, , Belgium
, Vancouver, British Columbia, Canada
, Toronto, Ontario, Canada
, Ostrava, , Czech Republic
, Praha, , Czech Republic
, Odense, , Denmark
, Paris, , France
, Rouen, , France
, Bad Berka, , Germany
, Grosshansdorf, , Germany
, Hamburg, , Germany
, Oldenburg, , Germany
, Hong Kong, , Hong Kong
, Hong Kong, , Hong Kong
, Budapest, , Hungary
, Edeleny, , Hungary
, Sopron, , Hungary
, Szombathely, , Hungary
, Torokbalint, , Hungary
, Milano, , Italy
, Milan, , Italy
, Orbassano, , Italy
, Roma, , Italy
, Den Haag, , Netherlands
, Enschede, , Netherlands
, Hoorn, , Netherlands
, Nieuwegein, , Netherlands
, Rotterdam, , Netherlands
, Poznan, , Poland
, Warszawa, , Poland
, Zabrze, , Poland
, Arkhangelsk, , Russian Federation
, Chelyabinsk, , Russian Federation
, Kazan, , Russian Federation
, Kazan, , Russian Federation
, Krasnodar, , Russian Federation
, Krasnodar, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Saint-Petersburg, , Russian Federation
, St Petersburg, , Russian Federation
, Barakaldo, Vizcaya, Spain
, Sevilla, , Spain
, Valencia, , Spain
, Valencia, , Spain
, Changhua, , Taiwan
, Taichung, , Taiwan
, Taichung, , Taiwan
, Taichung, , Taiwan
, Taipei, , Taiwan
, Aberdeen, , United Kingdom
, Chelmsford, , United Kingdom
, London, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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