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Brief Title: A Study of Ganetespib in Subjects With ALK-Positive Non-Small-Cell Lung Cancer (NSCLC)
Official Title: A Single Arm, Phase 2 Study of Ganetespib in Subjects With Advanced Non-Small-Cell Lung Cancer With Anaplastic Lymphoma Kinase Gene Rearrangement (ALK-Positive NSCLC)
Study ID: NCT01562015
Brief Summary: Phase 2 study of subjects with ALK positive, advanced NSCLC who have failed up to 3 prior therapies. The study will take place globally at multiple study centers. Subjects will be enrolled to receive ganetespib one time per week for three weeks followed by a rest week; and will repeat this schedule until the cancer gets worse or the subject is unable to tolerate ganetespib. The primary goal of the study is to determine how ganetespib is tolerated and how active it is in ALK positive NSCLC.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Synta Pharmaceuticals Investigative Site, Tampa, Florida, United States
Synta Pharmaceuticals Investigative Site, Cleveland, Ohio, United States
Synta Pharmaceuticals Investigative Site, Hamilton, Ontario, Canada
Synta Pharmaceuticals Investigative Site, Ottawa, Ontario, Canada
Synta Pharmaceuticals Investigative Site, Toronto, Ontario, Canada