Spots Global Cancer Trial Database for An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer
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Trial Identification
Brief Title: An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer
Official Title: A Phase 2, Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer
Study ID: NCT03915951
Conditions
Study Description
Brief Summary: This is an open-label, multicenter, non-randomized, Phase 2 study to determine the safety, tolerability and efficacy of encorafenib given in combination with binimetinib in patients with BRAFV600E-mutant metastatic non-small cell lung cancer (NSCLC). Patients who are either treatment-naïve, OR who have received 1) first-line treatment with standard platinum-based chemotherapy, OR 2) first-line treatment with an anti-programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) inhibitor given alone or in combination with platinum-based chemotherapy will be enrolled.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Yuma Regional Medical Center Cancer Center, Yuma, Arizona, United States
Yuma Regional Medical Center Ophthalmology, Yuma, Arizona, United States
Yuma Regional Medical Center, Yuma, Arizona, United States
UCLA Stein Eye Center Santa Monica (OPH), Santa Monica, California, United States
UCLA Hematology/Oncology, Santa Monica, California, United States
Florida Cancer Specialist, Altamonte Springs, Florida, United States
Florida Cancer Specialists, Bonita Springs, Florida, United States
Florida Cancer Specialist, Brandon, Florida, United States
Florida Cancer Specialists, Cape Coral, Florida, United States
Florida Cancer Specialist, Clearwater, Florida, United States
Florida Cancer Specialists, Fleming Island, Florida, United States
Florida Cancer Specialists, Fort Myers, Florida, United States
Florida Cancer Specialists, Fort Myers, Florida, United States
Florida Cancer Specialist, Gainesville, Florida, United States
Florida Cancer Specialists, Largo, Florida, United States
Florida Cancer Specialist, Lecanto, Florida, United States
Florida Cancer Specialists, Naples, Florida, United States
Florida Cancer Specialist, Ocala, Florida, United States
Florida Cancer Specialist, Orange City, Florida, United States
Florida Cancer Specialist, Orlando, Florida, United States
Florida Cancer Specialists, Port Charlotte, Florida, United States
Florida Cancer Specialist, Saint Petersburg, Florida, United States
Florida Cancer Specialists, Sarasota, Florida, United States
Florida Cancer Specialists, Sarasota, Florida, United States
Florida Cancer Specialists, Spring Hill, Florida, United States
Florida Cancer Specialists PAN - SCRI - PPDS, Tallahassee, Florida, United States
Florida Cancer Specialist, Tampa, Florida, United States
Florida Cancer Specialist, Tavares, Florida, United States
Florida Cancer Specialist, The Villages, Florida, United States
Florida Cancer Specialist, Trinity, Florida, United States
Florida Cancer Specialists, Venice, Florida, United States
Florida Cancer Specialists, Venice, Florida, United States
Florida Cancer Specialists, Winter Park, Florida, United States
Winship Cancer Institute @ Emory University Hospital Midtown, Atlanta, Georgia, United States
Emory University Hospital, Atlanta, Georgia, United States
Winship Cancer Institute, Emory University, Atlanta, Georgia, United States
Winship Cancer Institute @ Emory Saint Joseph's Hospital, Atlanta, Georgia, United States
Winship Cancer Institute @ Emory Johns Creek Hospital, Johns Creek, Georgia, United States
MidAmerica Division, Inc. c/o Menorah Medical Center, Overland Park, Kansas, United States
Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, United States
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, United States
The Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Ophthalmic Consultants of Boston (OCB), Boston, Massachusetts, United States
Ophthalmic Consultants of Boston Inc, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Brigham and Women's Hospital, Boston, Massachusetts, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center - 330 Brookline Ave, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center/East, Boston, Massachusetts, United States
Dana-Farber Cancer Institute - Chestnut Hill, Newton, Massachusetts, United States
Siteman Cancer Center - West County, Creve Coeur, Missouri, United States
MidAmerica Division, Inc. c/o Centerpoint Medical Center, Independence, Missouri, United States
MidAmerica Division, Inc., c/o Research Medical Center, Kansas City, Missouri, United States
Barnes-Jewish Hospital, Saint Louis, Missouri, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Siteman Cancer Center - South County, Saint Louis, Missouri, United States
Siteman Cancer Center - St Peters, Saint Peters, Missouri, United States
Memorial Sloan Kettering Cancer Center Basking Ridge, Basking Ridge, New Jersey, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
Metropolitan Eye Care, Paramus, New Jersey, United States
Memorial Sloan Kettering Cancer Center David H Koch Center for Cancer Care, New York, New York, United States
Weill Cornell Eye Associates, New York, New York, United States
Weill Cornell Medical College - New York Presbyterian Hospital, New York, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Weill Cornell Medical College - New York Presbyterian Hospital, New York, New York, United States
Duke Cancer Center, Durham, North Carolina, United States
Ohio State CarePoint East, Columbus, Ohio, United States
The Ohio State University East Hospital, Columbus, Ohio, United States
The Ohio State University Hospital, Columbus, Ohio, United States
The Ohio State University James Cancer Hospital, Columbus, Ohio, United States
The Ohio State University Medical Center - Thoracic Oncology Clinic, Columbus, Ohio, United States
Ohio State Eye and Ear Institute, Columbus, Ohio, United States
Stefanie Spielman Comprehensive Breast Cancer, Columbus, Ohio, United States
Martha Morehouse Medical Plaza, Columbus, Ohio, United States
Ohio State CarePoint Gahanna, Gahanna, Ohio, United States
Ohio State Outpatient Care Lewis Center, Lewis Center, Ohio, United States
The Ohio State University East Hospital Ohio State Outpatient Care New Albany, Westerville, Ohio, United States
Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon, United States
Providence Cancer Institute Newberg Clinic, Newberg, Oregon, United States
Providence Cancer Institute, Franz Clinic, Portland, Oregon, United States
Providence Oncology and Hematology Care Clinic - Westside, Portland, Oregon, United States
UPMC Hillman Cancer Center Erie, Erie, Pennsylvania, United States
UPMC Hillman Cancer Center - Arnold Palmer - Mt View, Greensburg, Pennsylvania, United States
UPMC Hillman Cancer Center Monroeville, Monroeville, Pennsylvania, United States
UPMC Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center - Passavant (HOA), Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center - Passavant (OHA), Pittsburgh, Pennsylvania, United States
UPMC Hillman Cancer Center - Upper St. Clair, Pittsburgh, Pennsylvania, United States
Weaver Eye Associates, York, Pennsylvania, United States
WellSpan Oncology Research, York, Pennsylvania, United States
Tennessee Oncology, PLLC, Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC, Cleveland, Tennessee, United States
Tennessee Oncology, PLLC, Dickson, Tennessee, United States
Tennessee Oncology, PLLC, Franklin, Tennessee, United States
Tennessee Oncology, PLLC, Gallatin, Tennessee, United States
Tennessee Oncology, PLLC, Hendersonville, Tennessee, United States
Tennessee Oncology, PLLC, Hermitage, Tennessee, United States
Tennessee Oncology, PLLC, Lebanon, Tennessee, United States
Tennessee Oncology, PLLC, Murfreesboro, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Shelbyville, Tennessee, United States
Tennessee Oncology, PLLC, Smyrna, Tennessee, United States
Houston Eye Associates - Gramercy Location, Houston, Texas, United States
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Millennium Research & Clinical Development, Houston, Texas, United States
Eye associates Northwest, Seattle, Washington, United States
Seattle Cancer Care Alliance, Seattle, Washington, United States
Departimento Oncologia Medica, Milan, Lombardia, Italy
Unita Operativa di Oculistica: UO Oncologia Oculare e Immunopatologia oculare, Milan, Lombardia, Italy
Unita Operativa Radiologia, Milan, Lombardia, Italy
UO Anatomia e lstologia Patologica, Milan, Lombardia, Italy
UO Dermatologia e Cosmetologia, Milan, Lombardia, Italy
UO Medicina Nucleare, Milan, Lombardia, Italy
S.S.D. Oncologia Polmonare, Orbassano, Torino, Italy
SCDO Cardiologia, Orbassano, Torino, Italy
SCDU Anatomia Patologica, Orbassano, Torino, Italy
SCDU Oftalmologia, Orbassano, Torino, Italy
SCDU Radiodiagnostica e S.S. Medicina Nucleare, Orbassano, Torino, Italy
Dermatologia Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino, TO, Italy
UO Dermatologia Centro Tumori Cutanei (CTC)- Azienda Ospedaliero, Bologna, , Italy
UO di Oftalmologia- Azienda Ospedaliero Universitaria Di Bologna, Bologna, , Italy
UO Medicina Borghi- Azienda Ospedaliero Universitaria Di Bologna, Bologna, , Italy
UO Radiologia Golfieri- Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi, Bologna, , Italy
UOC di Anatomia Patologica- Azienda Ospedaliero Universitaria Di Bo logna, Bologna, , Italy
IRCCS Ospedale San Raffaele, Milan, , Italy
Clinica Oculistica II, 2° Policlinico Federico II, Napli, , Italy
S. C. Farmacia, Napoli, , Italy
Samsung Medical Center - PPDS, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam, Noord-holland, Netherlands
Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam, , Netherlands
OLVG, locatie Oost; Ophthalmology department, Amsterdam, , Netherlands
Ophthalmology department, Groningen, , Netherlands
University Medical Center Groningen, Groningen, , Netherlands
Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda, Madrid, Spain
Hospital Regional Universitario de Malaga - Hospital General, Malaga, Málaga, Spain
Hospital Clinic de Barcelona, Badalona, , Spain
Hospital del Mar, Barcelona, , Spain
CETIR Centro Medico Teknon, Barcelona, , Spain
Hospital Quiron Salud Barcelona, Barcelona, , Spain
Hospital Universitario Vall d'Hebron, Barcelona, , Spain
Universitario Vall d'Hebron, Barcelona, , Spain
Grupo Cardiologico Corpal (Hospital de la Cruz Roja), Cordoba, , Spain
Hospital Universitario Reina Sofia, Cordoba, , Spain
Cetir, Esplugues de Llobregat, , Spain
lnstitut Catala d'Oncologia_L'Hospitalet, L'Hospitalet, , Spain
Hospital Universitario Ramon y Cajal, Madrid, , Spain
Hospital Universitario 12 de Octubre, Madrid, , Spain
Centro Hospitalario Integral Privado (CHIP), Malaga, , Spain
CERCO, Sevilla, , Spain
Hospital Universitario Virgen Macarena, Sevilla, , Spain
Hospital Universitario Virgen Del Rocio, Sevilla, , Spain
Contact Details
Name: Pfizer CT.gov Call Center
Affiliation: Pfizer
Role: STUDY_DIRECTOR
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