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Brief Title: Study of an Anti-HER3 Antibody, HMBD-001, With or Without Chemotherapy in Patients With Solid Tumors Harboring an NRG1 Fusion or HER3 Mutation
Official Title: A Phase 1b Study to Evaluate HMBD-001 With or Without Chemotherapy in Participants With Advanced Solid Tumors Harboring NRG1 Gene Fusions or Selected HER3 Mutations
Study ID: NCT05919537
Brief Summary: This is a phase 1b multi-center, open-label study of HMBD-001 with or without chemotherapy in participants with advanced solid tumors harboring NRG1 gene fusions or selected HER3 mutations.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
GenesisCare North Shore, Sydney, New South Wales, Australia
ICON Cancer Centre South Brisbane, Brisbane, Queensland, Australia
Southern Oncology Clinical Research Unit, Adelaide, South Australia, Australia
Cabrini Health, Malvern, Victoria, Australia
Linear Clinical Research, Perth, Western Australia, Australia