Spots Global Cancer Trial Database for Efficacy Study Comparing ZD6474 in Combination With Pemetrexed and Pemetrexed Alone in 2nd Line NSCLC Patients
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Trial Identification
Brief Title: Efficacy Study Comparing ZD6474 in Combination With Pemetrexed and Pemetrexed Alone in 2nd Line NSCLC Patients
Official Title: A Phase III, Randomized, Double-blinded, Parallel Group, Multi-centre Study to Assess the Efficacy and Safety of ZD6474 (ZACTIMA™) in Combination With Pemetrexed (Alimta®) Versus Pemetrexed Alone in Patients With Locally-Advanced or Metastatic NSCLC
Study ID: NCT00418886
Study Description
Brief Summary: Non-small cell lung cancer (NSCLC) can be treated with drugs that kill tumour cells, stop them from dividing, or stop the growth of the blood supply that cancers need to grow and spread. Clinical research has shown that drugs that inhibit vascular endothelial growth factor receptor (VEGFR) or epidermal growth factor receptor (EGFR) signalling can increase overall survival in patients with advanced non-small cell lung cancer (NSCLC). Preclinical studies have shown that vandetanib (ZD6474) is an inhibitor of both VEGFR and EGFR signalling. Giving vandetanib may therefore inhibit the growth of cancer cells by blocking their blood supply and by stopping them from dividing. This lung cancer study is to investigate if adding vandetanib to Alimta (pemetrexed) is more effective than Alimta (pemetrexed) alone.
Detailed Description: This randomized phase III non-small cell lung cancer clinical trial is studying the effect of Alimta (pemetrexed) plus vandetanib to see how well the combination works compared to Alimta (pemetrexed) alone in patients who have previously been treated for non-small cell lung cancer (NSCLC).
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Casa Grande, Arizona, United States
Research Site, Chandler, Arizona, United States
Research Site, Farmington, Connecticut, United States
Research Site, Stamford, Connecticut, United States
Research Site, Washington, District of Columbia, United States
Research Site, Orlando, Florida, United States
Research Site, Gainesville, Georgia, United States
Research Site, Skokie, Illinois, United States
Research Site, Sioux City, Iowa, United States
Research Site, Mount Sterling, Kentucky, United States
Research Site, Portland, Maine, United States
Research Site, Baltimore, Maryland, United States
Research Site, Rockville, Maryland, United States
Research Site, Boston, Massachusetts, United States
Research Site, Saint Louis, Missouri, United States
Research Site, Mineola, New York, United States
Research Site, Rochester, New York, United States
Research Site, Winston-Salem, North Carolina, United States
Research Site, Cincinnati, Ohio, United States
Research Site, Middletown, Ohio, United States
Research Site, Hilton Head Island, South Carolina, United States
Research Site, Austin, Texas, United States
Research Site, Salt Lake City, Utah, United States
Research Site, Avellaneda, , Argentina
Research Site, Buenos Aires, , Argentina
Research Site, Ciudad de Buenos Aires, , Argentina
Research Site, Córdoba, , Argentina
Research Site, La Plata, , Argentina
Research Site, Ramos Mejía, , Argentina
Research Site, Salta, , Argentina
Research Site, Santa Fe, , Argentina
Research Site, Chermside, , Australia
Research Site, Fitzroy, , Australia
Research Site, Footscray, , Australia
Research Site, Heidelberg, , Australia
Research Site, Randwick, , Australia
Research Site, St. Leonards, , Australia
Research Site, Wodonga, , Australia
Research Site, Brussels (Woluwé-St-Lambert), , Belgium
Research Site, Leuven, , Belgium
Research Site, Liège, , Belgium
Research Site, Bogota, , Colombia
Research Site, Medellín, , Colombia
Research Site, Pereira, , Colombia
Research Site, Valledupar, , Colombia
Research Site, Avignon Cedex 09, , France
Research Site, Lyon Cedex 04, , France
Research Site, Paris Cedex 15, , France
Research Site, Pontoise Cedex, , France
Research Site, Strasbourg Cedex, , France
Research Site, Hannover, , Germany
Research Site, Karlsruhe, , Germany
Research Site, Kassel, , Germany
Research Site, Köln, , Germany
Research Site, Leipzig, , Germany
Research Site, N. Faliro, , Greece
Research Site, Patras, , Greece
Research Site, Thessaloniki, , Greece
Research Site, Hong Kong, , Hong Kong
Research Site, Ahmedabad, , India
Research Site, Vellore, , India
Research Site, Beer-Sheeva, , Israel
Research Site, Haifa, , Israel
Research Site, Jerusalem, , Israel
Research Site, Kfar Saba, , Israel
Research Site, Petach-Tikva, , Israel
Research Site, Safed, , Israel
Research Site, Tel-Hashomer, , Israel
Research Site, Zerifin, , Israel
Research Site, Genova, , Italy
Research Site, Milano, , Italy
Research Site, Orbassano, , Italy
Research Site, Roma, , Italy
Research Site, S.Andrea Delle Fratte, , Italy
Research Site, Aguascalientes, , Mexico
Research Site, Mexico, , Mexico
Research Site, Puebla, , Mexico
Research Site, Cebu City, , Philippines
Research Site, Manila, , Philippines
Research Site, Pasay City, , Philippines
Research Site, Quezon City, , Philippines
Research Site, Lisboa, , Portugal
Research Site, Santa Maria da Feira, , Portugal
Research Site, Setúbal, , Portugal
Research Site, Cape Town, , South Africa
Research Site, Durban, , South Africa
Research Site, Johannesburg, , South Africa
Research Site, Port Elizabeth, , South Africa
Research Site, Pretoria, , South Africa
Research Site, A Coruña, , Spain
Research Site, Lugo, , Spain
Research Site, Majadahonda, , Spain
Research Site, Mataró(Barcelona), , Spain
Research Site, Málaga, , Spain
Research Site, Orense, , Spain
Research Site, Santiago De Compostela(A Coru, , Spain
Research Site, Vigo(Pontevedra), , Spain
Research Site, Lund, , Sweden
Research Site, Sundsvall, , Sweden
Research Site, Umeå, , Sweden
Research Site, Uppsala, , Sweden
Research Site, Västerås, , Sweden
Research Site, Taipei, , Taiwan
Research Site, Birmingham, , United Kingdom
Research Site, Edinburgh, , United Kingdom
Research Site, Leeds, , United Kingdom
Research Site, Manchester, , United Kingdom
Research Site, Wolverhampton, , United Kingdom
Research Site, Caracas, , Venezuela
Research Site, Valencia, , Venezuela
Contact Details
Name: Clinical Sciences & Operations
Affiliation: Sanofi
Role: STUDY_DIRECTOR
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