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Brief Title: Safety of Adding IMO-2055 to Erlotinib + Bevacizumab in 2nd Line Treatment for Patients With NSCLC
Official Title: Open-Label Phase 1b Study of Erlotinib Plus Bevacizumab and IMO-2055 in Patients With Non-Small Cell Lung Cancer Who Have Progressed Following Initial Chemotherapy for Advanced or Metastatic Disease
Study ID: NCT00633529
Brief Summary: To evaluate the safety of the proposed Phase II dosage of the investigational drug IMO 2055 when combined with erlotinib and bevacizumab in patients with previously treated advanced NSCLC.
Detailed Description: Phase 1b study of escalating doses of weekly subcutaneous IMO-2055 combined with fixed standard dose regimens of oral erlotinib (daily) and IV bevacizumab (every 3 weeks) in patients with previously treated advanced NSCLC.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Cancer Centers of Florida, Ocoee, Florida, United States
Central Indiana Cancer Centers, Indianapolis, Indiana, United States
New York Oncology Hematology P.C., Albany, New York, United States
Mary Crowley Medical Research Center, Dallas, Texas, United States
Cancer Therapy and Research Center, San Antonio, Texas, United States
Tyler Cancer Center, Tyler, Texas, United States
Virginia Oncology Associates, Norfolk, Virginia, United States
Northwest Cancer Specialists, Vancouver, Washington, United States
Yakima Valley Memorial Hospital/North Shore Cancer Lodge, Yakima, Washington, United States
Name: Phil Breitfeld, MD
Affiliation: EMD Serono
Role: STUDY_DIRECTOR